Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI036478-04S1
Application #
2549480
Study Section
Special Emphasis Panel (ZAI1-MSQ-M (O1))
Project Start
1994-09-15
Project End
2001-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Mehlotra, Rajeev K; Henry-Halldin, Cara N; Zimmerman, Peter A (2009) Application of pharmacogenomics to malaria: a holistic approach for successful chemotherapy. Pharmacogenomics 10:435-49
Mehlotra, Rajeev K; Mattera, Gabriel; Bockarie, Moses J et al. (2008) Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother 52:2212-22
Karl, Stephan; David, Makindi; Moore, Lee et al. (2008) Enhanced detection of gametocytes by magnetic deposition microscopy predicts higher potential for Plasmodium falciparum transmission. Malar J 7:66
Kasehagen, Laurin J; Mueller, Ivo; Kiniboro, Benson et al. (2007) Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes. PLoS One 2:e336
Mehlotra, Rajeev K; Bockarie, Moses J; Zimmerman, Peter A (2007) CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV/AIDS treatment. Br J Clin Pharmacol 64:391-5
Mehlotra, Rajeev K; Ziats, Mark N; Bockarie, Moses J et al. (2006) Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea. Eur J Clin Pharmacol 62:267-75
Mehlotra, Rajeev K; Mattera, Gabriel; Bhatia, Kuldeep et al. (2005) Insight into the early spread of chloroquine-resistant Plasmodium falciparum infections in Papua New Guinea. J Infect Dis 192:2174-9
Patel, Sheral S; King, Christopher L; Mgone, Charles S et al. (2004) Glycophorin C (Gerbich antigen blood group) and band 3 polymorphisms in two malaria holoendemic regions of Papua New Guinea. Am J Hematol 75:1-5
Zimmerman, Peter A; Patel, Sheral S; Maier, Alexander G et al. (2003) Erythrocyte polymorphisms and malaria parasite invasion in Papua New Guinea. Trends Parasitol 19:250-2
Maier, Alexander G; Duraisingh, Manoj T; Reeder, John C et al. (2003) Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med 9:87-92

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