Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI037554-02
Application #
2074344
Study Section
Immunobiology Study Section (IMB)
Project Start
1995-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Polakos, Noelle K; Klein, Ingo; Richter, Martin V et al. (2007) Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses. J Immunol 179:201-10
Crispe, Ian N; Giannandrea, Matthew; Klein, Ingo et al. (2006) Cellular and molecular mechanisms of liver tolerance. Immunol Rev 213:101-18
Polakos, Noelle K; Cornejo, Judith C; Murray, Debbie A et al. (2006) Kupffer cell-dependent hepatitis occurs during influenza infection. Am J Pathol 168:1169-78; quiz 1404-5
Jin, Young-Hee; Crispe, I Nicholas; Park, Sun (2005) Expression of hepatitis C virus core protein in hepatocytes does not modulate proliferation or apoptosis of CD8+ T cells. Yonsei Med J 46:827-34
John, Beena; Crispe, Ian Nicholas (2005) TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175:1643-50
John, Beena; Crispe, Ian Nicholas (2004) Passive and active mechanisms trap activated CD8+ T cells in the liver. J Immunol 172:5222-9
Murray, Debbie A; Crispe, I Nicholas (2004) TNF-alpha controls intrahepatic T cell apoptosis and peripheral T cell numbers. J Immunol 173:2402-9
Klugewitz, Katja; Blumenthal-Barby, Friderike; Schrage, Arnhild et al. (2002) Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization. J Immunol 169:2407-13
Dao, T; Exley, M; Mehal, W Z et al. (2001) Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol 166:3090-7
Mehal, W Z; Azzaroli, F; Crispe, I N (2001) Immunology of the healthy liver: old questions and new insights. Gastroenterology 120:250-60

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