Loss of TH1 Immune Function in Fiv Infected Cats

Tompkins, Mary B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI038177-02
• Application #: 2075116
• Study Section: AIDS and Related Research Study Section 3 (ARRC)
• Project Start: 1995-07-01
• Project End: 1999-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: North Carolina State University Raleigh
• Department: Microbiology/Immun/Virology
• Type: Schools of Veterinary Medicine
• City: Raleigh
• State: NC
• Country: United States
• Zip Code: 27695

Publications

Miller, Michelle M; Petty, Christopher S; Tompkins, Mary B et al. (2014) CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGF? / GARP-mediated mechanism. Virol J 11:7

Mexas, Angela M; Fogle, Jonathan E; Tompkins, Wayne A et al. (2008) CD4+CD25+ regulatory T cells are infected and activated during acute FIV infection. Vet Immunol Immunopathol 126:263-72

Tompkins, Mary B; Tompkins, Wayne A (2008) Lentivirus-induced immune dysregulation. Vet Immunol Immunopathol 123:45-55

Petty, Christopher S; Tompkins, Mary B; Tompkins, Wayne A (2008) Transforming growth factor-beta/transforming growth factor-betaRII signaling may regulate CD4+CD25+ T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection. J Acquir Immune Defic Syndr 47:148-60

Smithberg, S Rochelle; Fogle, Jonathan E; Mexas, Angela M et al. (2008) In vivo depletion of CD4+CD25+ regulatory T cells in cats. J Immunol Methods 329:81-91

Joshi, Anjali; Garg, Himanshu; Tompkins, Mary B et al. (2005) Different thresholds of T cell activation regulate FIV infection of CD4+CD25+ and CD4+CD25- cells. Virology 335:212-21

Vahlenkamp, Thomas W; Tompkins, Mary B; Tompkins, Wayne A F (2005) The role of CD4+CD25+ regulatory T cells in viral infections. Vet Immunol Immunopathol 108:219-25

Joshi, Anjali; Garg, Himanshu; Tompkins, Mary B et al. (2005) Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors. J Virol 79:4965-76

Vahlenkamp, Thomas W; Bull, Marta E; Dow, Janet L et al. (2004) B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion. Vet Immunol Immunopathol 98:203-14

Joshi, Anjali; Vahlenkamp, Thomas W; Garg, Himanshu et al. (2004) Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation. Virology 321:307-22