Abstract

The applicant hypothesis is that immunity to Entamoeba histolytica infection is acquired from previous infection.
In specific aim 1 a 3 years prospective study will measure E. histolytica infection and invasion in cohorts of children ages 2-5 in the Mirpur district of Dhaka. If the hypothesis is correct they would predict that following outcomes: a) Children who had prior E. histolytica infection will be less likely to have future of invasive amebiasis; b) it is possible that they will also be less likely to be reinfected with E. histolytica; and, c) if reinfected may clear infection more rapidly. If their hypothesis is correct they would predict that clearance of E. histolytica infection will be associated with the development of an adherence-inhibitory antibody response against the carbohydrate-binding domain of the lectin. Completion of these studies should provide a foundation for understanding the mechanisms of protective immunity to amebiasis, and provide a baseline for evaluating the efficacy of vaccines as they enter clinical trails.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI043596-02
Application #
2887824
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Program Officer
Hall, B Fenton
Project Start
1998-09-15
Project End
2002-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Uchiyama, Robin; Kupkova, Kristyna; Shetty, Savera J et al. (2018) Histone H3 lysine 4 methylation signature associated with human undernutrition. Proc Natl Acad Sci U S A 115:E11264-E11273
Steiner, Kevin L; Ahmed, Shahnawaz; Gilchrist, Carol A et al. (2018) Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study. Clin Infect Dis 67:1347-1355
Rogawski, Elizabeth T; Platts-Mills, James A; Colgate, E Ross et al. (2018) Quantifying the Impact of Natural Immunity on Rotavirus Vaccine Efficacy Estimates: A Clinical Trial in Dhaka, Bangladesh (PROVIDE) and a Simulation Study. J Infect Dis 217:861-868
Kabir, Mamun; Ahmed, Emtiaz; Hossain, Biplob et al. (2018) Giardia/Cryptosporidium QUIK CHEK Assay Is More Specific Than Quantitative Polymerase Chain Reaction for Rapid Point-of-care Diagnosis of Cryptosporidiosis in Infants in Bangladesh. Clin Infect Dis 67:1897-1903
Khalil, Ibrahim A; Troeger, Christopher; Rao, Puja C et al. (2018) Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study. Lancet Glob Health 6:e758-e768
Donowitz, Jeffrey R; Cook, Heather; Alam, Masud et al. (2018) Role of maternal health and infant inflammation in nutritional and neurodevelopmental outcomes of two-year-old Bangladeshi children. PLoS Negl Trop Dis 12:e0006363
Jiang, Nona M; Cowan, Maureen; Moonah, Shannon N et al. (2018) The Impact of Systemic Inflammation on Neurodevelopment. Trends Mol Med 24:794-804
Schnee, Amanda E; Haque, Rashidul; Taniuchi, Mami et al. (2018) Evaluation of Two New Membrane-Based and Microtiter Plate Enzyme-Linked Immunosorbent Assays for Detection of Campylobacter jejuni in Stools of Bangladeshi Children. J Clin Microbiol 56:
Korpe, Poonum S; Valencia, Cristian; Haque, Rashidul et al. (2018) Epidemiology and Risk Factors for Cryptosporidiosis in Children From 8 Low-income Sites: Results From the MAL-ED Study. Clin Infect Dis 67:1660-1669
Gilchrist, Carol A; Cotton, James A; Burkey, Cecelia et al. (2018) Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing. J Infect Dis 218:259-264

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