This project describes the systematic development of antimycobacterial agents targeting the unique nature of the lipid components of the bacterial cell wall. The approaches are designed specifically to inhibit the activities of the b-keto-acyl-synthases which generate the long chain fatty acids. The strategy is based on the natural product lead compounds cerulinin and thiolactomycin both of which show activity against FAS I and II activities, and are active against M.avium and M. tuberculosis in vitro. Generation of synthetic analogues has lead to the identification of compound III-50 which shows activity both in vitro and in in vivo murine TB.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI043846-05
Application #
6511073
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Program Officer
Near, Karen A
Project Start
1998-08-01
Project End
2003-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
5
Fiscal Year
2002
Total Cost
$306,611
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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