Public Health Relevance

Microbial pathogens must respond to the host environment in order to survive and cause successful infection. The ability to integrate these diverse signals requires a concert of sensory systems that direct the transcriptional machinery to effect specific bacterial gene expression. The project is focused on understanding the genetic control of these mechanisms. This research is broadly applicable to many bacterial pathogens and may be used to develop new methods to combat infectious diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI048622-08
Application #
7932893
Study Section
Bacterial Pathogenesis Study Section (BACP)
Program Officer
Alexander, William A
Project Start
2009-09-17
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
8
Fiscal Year
2010
Total Cost
$390,000
Indirect Cost
Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Will, W Ryan; Bale, Denise H; Reid, Philip J et al. (2014) Evolutionary expansion of a regulatory network by counter-silencing. Nat Commun 5:5270
Fritsche, Gernot; Nairz, Manfred; Libby, Stephen J et al. (2012) Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol 92:353-9
Libby, Stephen J; Brehm, Michael A; Greiner, Dale L et al. (2010) Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107:15589-94
Fang, Ferric C; Rimsky, Sylvie (2008) New insights into transcriptional regulation by H-NS. Curr Opin Microbiol 11:113-20