The objectives of this application are to study the association of dietary and serum antioxidants and oxidative stress on adult-onset asthma incidence among a cohort of 75,000 women. We hypothesize that dietary antioxidants play a role in the development of asthma, particularly in persons with a family history of atopic disease. Questions related to dietary antioxidant intake that this application aims to address are whether dietary and serum antioxidants protect against development of adult-onset asthma, whether persons with atopic disease have higher indices of oxidative stress, and whether those with a genetic susceptibility to be atopic are protected by higher intake of dietary antioxidants. To examine these hypotheses, we will utilize an existing large prospective cohort, the Shanghai Women's Health Study (SWHS), which tracks detailed information on dietary intake and environmental factors as they relate to cancer incidence and other chronic diseases. This prospective cohort study is being conducted among approximately 75,000 female residents of Shanghai, China between the ages of 35 and 69, where there is marked heterogeneity in dietary intake and 97 percent of the cohort are non-smokers. Measurements of free radicals will be made in baseline urine samples using an assay for isoprostanes, recently described lipid peroxidation products, to determine if there is a correlation between adult-onset asthma and increased markers of lipid peroxidation. Isoprostanes are considered the most accurate marker of oxidative stress currently available. Measurements of serum antioxidants will be made using baseline serum samples. We propose in this project: (1) an incidence study to determine the association between dietary antioxidants and incident asthma, and (2) a nested case control study examining (a) the correlation between a urinary measure of oxidative stress and incident asthma, and (b) the relationship between serum antioxidants and incident asthma. This series of studies, with the combination of three measures of antioxidant exposure and oxidant stress, are designed to uncover antioxidant-specific effects in the development of asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI050884-03
Application #
6865646
Study Section
Special Emphasis Panel (ZRG1-EDC-3 (01))
Program Officer
Plaut, Marshall
Project Start
2003-08-01
Project End
2008-01-31
Budget Start
2005-02-01
Budget End
2006-01-31
Support Year
3
Fiscal Year
2005
Total Cost
$684,020
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Cook-Mills, Joan; Gebretsadik, Tebeb; Abdala-Valencia, Hiam et al. (2016) Interaction of vitamin E isoforms on asthma and allergic airway disease. Thorax 71:954-6
Larkin, Emma K; Gao, Yu-Tang; Gebretsadik, Tebeb et al. (2015) New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. Am J Respir Crit Care Med 191:45-53
Deng, Xinqing; Gebretsadik, Tebeb; Jin, Meiling et al. (2010) Development of a nomogram for identification of asthma among adults in epidemiologic studies. Ann Allergy Asthma Immunol 105:203-10
Carroll, Kecia N; Wu, Pingsheng; Gebretsadik, Tebeb et al. (2009) Season of infant bronchiolitis and estimates of subsequent risk and burden of early childhood asthma. J Allergy Clin Immunol 123:964-6
Carroll, Kecia N; Hartert, Tina V (2008) The impact of respiratory viral infection on wheezing illnesses and asthma exacerbations. Immunol Allergy Clin North Am 28:539-61, viii
Hartert, Tina V; Deng, Xinqing; Hartman, Terryl J et al. (2008) The Shanghai Women's Asthma and Allergy Study: objectives, design, and recruitment results. Am J Epidemiol 167:1387-96
Miller, E Kathryn; Lu, Xiaoyan; Erdman, Dean D et al. (2007) Rhinovirus-associated hospitalizations in young children. J Infect Dis 195:773-81
Wu, Pingsheng; Roberts 2nd, Lyman J; Shintani, Ayumi K et al. (2007) Changes in urinary dinor dihydro F(2)-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations. Free Radic Res 41:956-62
Whalen, Ursula; Griffin, Marie R; Shintani, Ayumi et al. (2006) Smoking rates among pregnant women in Tennessee, 1990-2001. Prev Med 43:196-9
Venarske, Daniel L; Busse, William W; Griffin, Marie R et al. (2006) The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking. J Infect Dis 193:1536-43

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