Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI052435-02
Application #
6796731
Study Section
Immunobiology Study Section (IMB)
Program Officer
Ridge, John P
Project Start
2003-09-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$255,500
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Whitfield-Larry, Fatima; Young, Ellen F; Talmage, Garrick et al. (2011) HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/ýýc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 60:1726-33
Vincent, Benjamin G; Young, Ellen F; Buntzman, Adam S et al. (2010) Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice. J Immunol 184:4196-204
Li, Chengwen; Goudy, Kevin; Hirsch, Matt et al. (2009) Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proc Natl Acad Sci U S A 106:10770-4
Young, Ellen F; Hess, Paul R; Arnold, Larry W et al. (2009) Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct. Autoimmunity 42:678-91
Frelinger, Jeffrey A (2008) Novel epitope begets a novel pathway in type 1 diabetes progression. J Clin Invest 118:3268-71
Wong, Carmen P; Stevens, Rosemary; Long, Brian et al. (2007) Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets. J Immunol 178:1388-95
Maile, Robert; Pop, Shannon M; Tisch, Roland et al. (2006) Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. Eur J Immunol 36:397-410
Long, Brian; Wong, Carmen P; Wang, Yaming et al. (2006) Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice. Eur J Immunol 36:2003-12
Wong, Carmen P; Li, Li; Frelinger, Jeffrey A et al. (2006) Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice. J Immunol 176:1637-44
Maile, Robert; Siler, Catherine A; Kerry, Samantha E et al. (2005) Peripheral ""CD8 tuning"" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol 174:619-27

Showing the most recent 10 out of 11 publications