Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI056139-02
Application #
6755093
Study Section
Experimental Immunology Study Section (EI)
Program Officer
Rathbun, Gary
Project Start
2003-06-15
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$382,500
Indirect Cost
Name
Washington University
Department
Pathology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Tassi, Ilaria; Cella, Marina; Castro, Iris et al. (2009) Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization. Eur J Immunol 39:1369-78
Tassi, Ilaria; Le Friec, Gaelle; Gilfillan, Susan et al. (2009) DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo. Eur J Immunol 39:1129-35
Cella, Marina; Fuchs, Anja; Vermi, William et al. (2009) A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457:722-5
Gilfillan, Susan; Chan, Christopher J; Cella, Marina et al. (2008) DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med 205:2965-73
Tassi, Ilaria; Cella, Marina; Presti, Rachel et al. (2008) NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion. Blood 112:4109-16
Tassi, Ilaria; Cella, Marina; Gilfillan, Susan et al. (2007) p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity 27:214-27
Blasius, Amanda L; Barchet, Winfried; Cella, Marina et al. (2007) Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells. J Exp Med 204:2561-8
Stewart, C A; Vivier, E; Colonna, M (2006) Strategies of natural killer cell recognition and signaling. Curr Top Microbiol Immunol 298:1-21
Tassi, Ilaria; Colonna, Marco (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol 175:7996-8002
Tassi, Ilaria; Presti, Rachel; Kim, Sungjin et al. (2005) Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol 175:749-54

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