The Fox/forkhead family encompasses an ever-growing number of helix-loop-helix transcription factors that participate in diverse biological systems. We describe here an immune role for Foxj1, a Fox family member originally characterized for its role in ciliated epithelial cells. In its absence, helper T (Th) cells are characterized by Th1-skewed hyperproliferation, associated with multi-system auto-inflammation. As such, Foxj1 plays a critical role in the maintenance of T cell quiescence and/or immune tolerance, but we know relatively little about its mechanism of action, as well as its contextual importance in T cell activation. We therefore propose in this application to delve further into the role of Foxj1 in T cell biology - in particular to examine more completely its role in Th proliferation and activation, to determine more fully its relevance to autoimmunity, and to elucidate the molecular pathway in which it operates. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI061478-01
Application #
6815681
Study Section
Allergy and Immunology Study Section (ALY)
Program Officer
Esch, Thomas R
Project Start
2004-07-01
Project End
2009-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$344,250
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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