Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI072479-05
Application #
7998206
Study Section
Bacterial Pathogenesis Study Section (BACP)
Program Officer
Hall, Robert H
Project Start
2007-01-01
Project End
2013-06-30
Budget Start
2011-01-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$371,951
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Liu, Zhi; Wang, Hui; Zhou, Zhigang et al. (2016) Differential Thiol-Based Switches Jump-Start Vibrio cholerae Pathogenesis. Cell Rep 14:347-54
Katzianer, David S; Wang, Hui; Carey, Ryan M et al. (2015) "Quorum Non-Sensing": Social Cheating and Deception in Vibrio cholerae. Appl Environ Microbiol 81:3856-62
Rothenbacher, Francesca P; Zhu, Jun (2014) Efficient responses to host and bacterial signals during Vibrio cholerae colonization. Gut Microbes 5:120-8
Lasaro, Melissa; Liu, Zhi; Bishar, Rima et al. (2014) Escherichia coli isolate for studying colonization of the mouse intestine and its application to two-component signaling knockouts. J Bacteriol 196:1723-32
Stern, Andrew M; Hay, Amanda J; Liu, Zhi et al. (2012) The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines. MBio 3:e00013-12
Wang, Hui; Chen, Shusu; Zhang, Juan et al. (2012) Catalases promote resistance of oxidative stress in Vibrio cholerae. PLoS One 7:e53383
Tsou, Amy M; Liu, Zhi; Cai, Tao et al. (2011) The VarS/VarA two-component system modulates the activity of the Vibrio cholerae quorum-sensing transcriptional regulator HapR. Microbiology 157:1620-8
Liu, Zhi; Yang, Menghua; Peterfreund, Gregory L et al. (2011) Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB. Proc Natl Acad Sci U S A 108:810-5
Wang, Yunduan; Wang, Hui; Cui, Zhigang et al. (2011) The Prevalence of Functional Quorum-Sensing Systems in Recently Emerged Vibrio cholerae Toxigenic Strains. Environ Microbiol Rep 3:218-222
Xu, Xiao; Stern, Andrew M; Liu, Zhi et al. (2010) Virulence regulator AphB enhances toxR transcription in Vibrio cholerae. BMC Microbiol 10:3

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