Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called """"""""virulence factors"""""""" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine.

Public Health Relevance

Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called """"""""virulence factors"""""""" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI083084-04
Application #
8308963
Study Section
Special Emphasis Panel (ZRG1-IDM-P (50))
Program Officer
Lacourciere, Karen A
Project Start
2009-08-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$75,742
Indirect Cost
$4,526
Name
National Institute of Agriculture Tech
Department
Type
DUNS #
970000209
City
Buenos Aires
State
Country
Argentina
Zip Code
Forrellad, Marina Andrea; McNeil, Michael; Santangelo, María de la Paz et al. (2014) Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis. Tuberculosis (Edinb) 94:170-7
Blanco, Federico Carlos; Bigi, Fabiana; Soria, Marcelo Abel (2014) Identification of potential biomarkers of disease progression in bovine tuberculosis. Vet Immunol Immunopathol 160:177-83
Forrellad, Marina A; Klepp, Laura I; Gioffre, Andrea et al. (2013) Virulence factors of the Mycobacterium tuberculosis complex. Virulence 4:3-66
Forrellad, Marina Andrea; Bianco, María Verónica; Blanco, Federico Carlos et al. (2013) Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis. BMC Microbiol 13:200
Blanco, Federico Carlos; Soria, Marcelo; Gravisaco, Maria Jose et al. (2012) Assessment of the immune responses induced in cattle after inoculation of a Mycobacterium bovis strain deleted in two mce2 genes. J Biomed Biotechnol 2012:258353
Rizzi, Caroline; Bianco, Maria Veronica; Blanco, Federico Carlos et al. (2012) Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge. PLoS One 7:e51396
Klepp, Laura I; Forrellad, Marina A; Osella, Ana V et al. (2012) Impact of the deletion of the six mce operons in Mycobacterium smegmatis. Microbes Infect 14:590-9
Bianco, Maria V; Blanco, Federico C; Imperiale, Belen et al. (2011) Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds. BMC Infect Dis 11:195
Blanco, Federico Carlos; Bianco, Maria Veronica; Meikle, Virginia et al. (2011) Increased IL-17 expression is associated with pathology in a bovine model of tuberculosis. Tuberculosis (Edinb) 91:57-63