Impacts of Urbanization on Vector Biology and Transmission of Dengue in China. Dengue is a major public health problem in southern China. In recent years, the epidemic interval of Dengue outbreaks in southern China has become shorter and the epidemic area is expanding. Because Dengue epidemics coincide with rapid urbanization in China as a result of economic development, it has been suggested that urbanization creates favorable conditions for the survival and reproduction of Dengue vectors and for the transmission of Dengue virus. This application tests the central hypothesis that environmental changes resulting from urbanization affect the biology and vectorial capacity of Aedes albopictus, the major Dengue vector in southern China. We will further examine the molecular epidemiology of the Dengue virus in urban areas for major outbreaks in Guangzhou city in the past two decades. The long-term goal of this research is to determine the mechanisms of Dengue epidemics in urban environments and to develop effective prevention and control methods. We have designed the following two specific aims. First, we will determine the impact of urbanization on the larval and adult ecology of Aedes albopictus mosquitoes, the sole Dengue vector in the Guangzhou area where the present study will be conducted.
This aim will test the hypothesis that urbanization creates favorable conditions for the survivorship and development of Aedes albopictus larvae and subsequently, increases the abundance of the Dengue vector. Second, we will determine the transmission patterns of Dengue virus in urban environments.
This aim will test the hypothesis that Dengue outbreaks are associated with the introduction and circulation of new serotypes or genotypes of Dengue virus, and that vector competence of Ae. albopictus varies among Dengue viral serotypes and genotypes, and thus the most favored DENV serotype/genotype may become the epidemic type. The proposed research takes advantage of the unique Dengue epidemiological and vector population situations in Guangzhou, China where frequent Dengue outbreaks have occurred and Ae. albopictus is actively breeding in the urban environment. This research will significantly enhance our understanding of Dengue transmission in urban areas, and contribute to the development of effective surveillance and control programs of Dengue in China.

Public Health Relevance

Dengue causes a major public health problem in China;however the mechanisms for increased frequencies and magnitude of Dengue are not clear. The present proposal will use to test the central hypothesis that environmental changes resulting from urbanization affect the biology and vectorial capacity of Ae. albopictus, the major vector of Dengue virus in southern China. The result of this research will be useful to determine the mechanisms of Dengue epidemics and develop effective prevention and control methods for Dengue.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-IDM-R (50))
Program Officer
Costero, Adriana
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Southern Medical University
Zip Code
Zhang, H; Zhou, Y P; Peng, H J et al. (2014) Predictive symptoms and signs of severe dengue disease for patients with dengue fever: a meta-analysis. Biomed Res Int 2014:359308
Qin, Qian; Li, Yiji; Zhong, Daibin et al. (2014) Insecticide resistance of Anopheles sinensis and An. vagus in Hainan Island, a malaria-endemic area of China. Parasit Vectors 7:92
Wei, Yuehong; Huang, Yong; Luo, Lei et al. (2014) Rapid increase of scrub typhus: an epidemiology and spatial-temporal cluster analysis in Guangzhou City, Southern China, 2006-2012. PLoS One 9:e101976
Zhang, Hao; Li, Wei; Wang, Junjie et al. (2014) NS1-based tests with diagnostic utility for confirming dengue infection: a meta-analysis. Int J Infect Dis 26:57-66
Zhang, Hao; Zhang, Yanru; Hamoudi, Rifat et al. (2014) Spatiotemporal characterizations of dengue virus in mainland China: insights into the whole genome from 1978 to 2011. PLoS One 9:e87630
Bonizzoni, Mariangela; Gasperi, Giuliano; Chen, Xioaguang et al. (2013) The invasive mosquito species Aedes albopictus: current knowledge and future perspectives. Trends Parasitol 29:460-8
Luo, Lei; Liang, Hui-ying; Jing, Qin-long et al. (2013) Molecular characterization of the envelope gene of dengue virus type 3 newly isolated in Guangzhou, China, during 2009-2010. Int J Infect Dis 17:e498-504
Jiang, Liyun; Wu, Xinwei; Wu, Yejian et al. (2013) Molecular epidemiological and virological study of dengue virus infections in Guangzhou, China, during 2001-2010. Virol J 10:4
Zhong, Daibin; Lo, Eugenia; Hu, Renjie et al. (2013) Genetic analysis of invasive Aedes albopictus populations in Los Angeles County, California and its potential public health impact. PLoS One 8:e68586