There is no proven effective prevention intervention specifically for men who have sex with men (MSM) population. Bundling partial measures and optimize combinations of interventions may have a substantial impact on HIV seroincidence. The goal of this study is to develop and pilot test a package of Test and Link-to-Care (TLC)-based interventions for preparation of future community-level randomized clinical trial.
The specific aims are: (1) To conduct a systematic review of the literature and mathematical modeling to guide the selection of HIV prevention interventions for MSM in China;(2) To conduct a pilot study to evaluate the feasibility, acceptability and initial efficacy of a multi-component TLC intervention packages among MSM in China;and (3) To refine and finalize menu-driven HIV prevention packages and design a multi-site randomized clinical trial in 12 Chinese cities to evaluate its impact on HIV seroincidence among Chinese MSM. As a team of an expert network of American and Chinese researchers and community members with rich knowledge in the subject domains and substantial experience in China, we will develop a culturally competent and potentially effective intervention packages for Chinese MSM at the end of this project. The rapid rise of HIV epidemic among Chinese MSM and the comprehensive disease prevention networks in China provide unique environment for conducting a large scale community-based clinical trial.

Public Health Relevance

These sustainable intervention packages, if proven feasible and effective, will be adopted in future research and public health programs for preventing new HIV infections and improving the lives of HIV-infected MSM. This MP3 grant is to develop and pilot test a multi-components prevention intervention package of Test and Link-to-Care (TLC) strategy to reduce HIV transmission by engaging expanded HIV testing with prompt initiation of risk reduction intervention and optimal antiretroviral treatment among a HIV high risk but largely ignored population-men who have sex with men (MSM) in China. These sustainable intervention packages, if proven feasible and effective, will be adopted in future research and public health programs for preventing new HIV infections and improving the lives of HIV-infected MSM in China and other parts of the world.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI094562-03
Application #
8436251
Study Section
Special Emphasis Panel (ZAI1-BLG-A (J1))
Program Officer
Chow, Grace C
Project Start
2011-03-15
Project End
2015-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
3
Fiscal Year
2013
Total Cost
$556,878
Indirect Cost
$116,276
Name
Vanderbilt University Medical Center
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Li, Xingguang; Zai, Junjie; Liu, Haizhou et al. (2016) The 2014 Ebola virus outbreak in West Africa highlights no evidence of rapid evolution or adaptation to humans. Sci Rep 6:35822
Feng, Yi; Takebe, Yutaka; Wei, Huamian et al. (2016) Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC. Sci Rep 6:19279
Zhang, Chen; Qian, Han-Zhu; Yin, Lu et al. (2016) Sexual Behaviors Linked to Drug and Alcohol Use Among Men Who Have Sex With Men in China. Subst Use Misuse 51:1821-30
Zhang, Heng; Teng, Tao; Lu, Hongyan et al. (2016) Poppers use and risky sexual behaviors among men who have sex with men in Beijing, China. Drug Alcohol Depend 160:42-8
Liu, Yu; Wang, Juan; Qian, Han-Zhu et al. (2016) Seeking Male Sexual Partners via Internet and Traditional Venues among Chinese Men Who Have Sex with Men: Implications for HIV Risk Reduction Interventions. AIDS Behav 20:2222-30
Liu, Yu; Osborn, Chandra Y; Qian, Han-Zhu et al. (2016) Barriers and Facilitators of Linkage to and Engagement in HIV Care Among HIV-Positive Men Who Have Sex with Men in China: A Qualitative Study. AIDS Patient Care STDS 30:70-7
Qian, Han-Zhu; Ruan, Yuhua; Liu, Yu et al. (2016) Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China: Interaction With Anal Sex Role in a Cross-Sectional Study. J Acquir Immune Defic Syndr 71:444-51
Tao, Jun; Wang, Lijuan; Kipp, Aaron M et al. (2016) Relationship of Stigma and Depression Among Newly HIV-Diagnosed Chinese Men Who Have Sex with Men. AIDS Behav :
Liu, Yu; Qian, Han-Zhu; Ruan, Yuhua et al. (2016) Frequent HIV Testing: Impact on HIV Risk Among Chinese Men Who Have Sex with Men. J Acquir Immune Defic Syndr 72:452-61
Liu, Yu; Ruan, Yuhua; Vermund, Sten H et al. (2015) Predictors of antiretroviral therapy initiation: a cross-sectional study among Chinese HIV-infected men who have sex with men. BMC Infect Dis 15:570

Showing the most recent 10 out of 26 publications