Viruses Strategies for control of influenza and other respiratory infections have been based on models using assumptions derived from the Tecumseh Study of Respiratory Illness, conducted 30 years ago. Since that time, laboratory and analytic methods have markedly advanced. We have recruited more than 300 households with children for a longitudinal study of respiratory illnesses. We propose to determine the incidence and characteristics of respiratory infections by collecting specimens from subjects with respiratory illness meeting a case definition, and testing specimens using PCR to identify influenza and other respiratory viruses. To determine susceptibility to influenza, and immunologic response to infection and vaccination, blood specimens will be collected at three points annually, and tested in hemagglutination inhibition (HAI), microneutralization and other assays to measure influenza specific antibody titers and changes in titers between specimens. Both standard techniques and dynamic transmission models will be used in data analysis. Household infection rates and the effects of crowding and humidity will be determined. Secondary spread, conditioned on susceptibility will be calculated. Transmission in schools and the overall community will be compared with those in the household. Results will provide an updated scientific basis for determining control strategies.

Public Health Relevance

Understanding the occurrence of influenza and other respiratory viruses and how they are transmitted is essential for successful control. We propose to study these illnesses in households with children and use the collected data to identify factors involved in transmission, in the household and community, using a variety of analytic techniques.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Project (R01)
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Clinical Research and Field Studies of Infectious Diseases Study Section (CRFS)
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Stemmy, Erik J
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University of Michigan Ann Arbor
Public Health & Prev Medicine
Schools of Public Health
Ann Arbor
United States
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Ohmit, Suzanne E; Petrie, Joshua G; Malosh, Ryan E et al. (2016) Substantial Influenza Vaccine Effectiveness in Households With Children During the 2013-2014 Influenza Season, When 2009 Pandemic Influenza A(H1N1) Virus Predominated. J Infect Dis 213:1229-36
Petrie, Joshua G; Parkhouse, Kaela; Ohmit, Suzanne E et al. (2016) Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains. J Infect Dis 214:1947-1951
Ohmit, Suzanne E; Petrie, Joshua G; Malosh, Ryan E et al. (2015) Influenza vaccine effectiveness in households with children during the 2012-2013 season: assessments of prior vaccination and serologic susceptibility. J Infect Dis 211:1519-28
Monto, Arnold S; Malosh, Ryan E; Petrie, Joshua G et al. (2014) Frequency of acute respiratory illnesses and circulation of respiratory viruses in households with children over 3 surveillance seasons. J Infect Dis 210:1792-9
Malosh, Ryan; Ohmit, Suzanne E; Petrie, Joshua G et al. (2014) Factors associated with influenza vaccine receipt in community dwelling adults and their children. Vaccine 32:1841-7
Petrie, Joshua G; Ohmit, Suzanne E; Cowling, Benjamin J et al. (2013) Influenza transmission in a cohort of households with children: 2010-2011. PLoS One 8:e75339