With its dense interacting populations of people, pigs, and poultry, China has been implicated as the source of the 1957 and 1968 pandemic influenza viruses and considered an epicenter for generating novel influenza virus strains. As industrialized farming has increased in China, the prevalence and variety of swine influenza viruses (SIVs) have increased. In this controlled, 5-yr project, we will collaborate with leading Chinese infectious disease researchers and employ a One Health approach (human, animal, and environment) to study SIV transmission in Confined Animal Feeding Operations (CAFOs) in mainland China. We will select CAFOs with a high prevalence of SIVs and prospectively follow the swine workers and their pigs, as well as examine the CAFO environment as a source for SIV persistence and transmission. In this collaboration, our aims are: 1) to identify and characterize enzootic and emergent SIVs, 2) to employ aerosol, fecal, environmental swabs, and water sampling to identify environmental areas with a high prevalence of SIVs, 3) to identify occupational risk factors for SIV infection, and 4) to identify serological and mucosal immunity biomarkers of protection against prevalent and emergent SIVs. This One Health approach to zoonotic influenza virus research is unique and made possible by our Chinese collaborators who have unique access to their swine production industry.

Public Health Relevance

Reports of human infections with swine influenza viruses (SIVs) are increasing. Identifying environmental and occupational risk factors for SIV infection as well as determining immunological and mucosal biomarkers for immune protection will lead to new interventions for better influenza control.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI108993-01A1
Application #
8761305
Study Section
Clinical Research and Field Studies of Infectious Diseases Study Section (CRFS)
Program Officer
Stemmy, Erik J
Project Start
2014-08-15
Project End
2019-07-31
Budget Start
2014-08-15
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$437,777
Indirect Cost
$128,194
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705