The global AIDS epidemic is one of the greatest threats to human health and development. Countries need to ground their AIDS strategies in an understanding of their own epidemics and their national re- sponses. A reliable estimation and prediction on the HIV/AIDS epidemic can help policy makers and program planners ef?ciently allocate the resource, plan and manage the intervention, treatment and care programs, evaluate their effort, and raise funds. The epidemiological model called ?EPP? has been used by the UNAIDS and most countries in the world for estimation and short-term prediction of HIV/AIDS trends from limited surveillance data since 2001. As the epidemic enters its fourth decade, both the epidemic and monitoring data sources have changed signi?cantly. The existing models are no longer capable of capturing the epidemic trend accu- rately. In this proposal, we plan to develop new statistical models to estimate and project the epidemic that re?ect those changes and utilize new data sources, with the following aims. 1. Incorporate new sources of data in current mathematical models to strengthen the epidemic esti- mates for high HIV prevalence countries (known as generalized epidemic). 2. Develop hierarchical models to provide reliable estimates of HIV epidemics for sub-national areas and key populations who are at higher risk for HIV, based on sexual practices, occupations, and substance use. 3. Develop Bayesian models to improve the estimation of key population sizes. 4. We will produce freely-available, open-source software to implement all of the proposed models and methods.
Fighting the AIDS epidemic is one of the most effective global movements of this generation. The foundation of all of the efforts to end the epidemic is an accurate estimation and projection of the epidemic, for the general population as well as the key population, globally and locally. Our goal in this proposal is to develop new approaches that will adequately use available data sources and yield reliable estimates and realistic projections of HIV/AIDS epidemics.
|Sheng, Ben; Marsh, Kimberly; Slavkovic, Aleksandra B et al. (2017) Statistical models for incorporating data from routine HIV testing of pregnant women at antenatal clinics into HIV/AIDS epidemic estimates. AIDS 31 Suppl 1:S87-S94|
|Niu, Xiaoyue; Zhang, Amy; Brown, Tim et al. (2017) Incorporation of hierarchical structure into estimation and projection package fitting with examples of estimating subnational HIV/AIDS dynamics. AIDS 31 Suppl 1:S51-S59|
|Eaton, Jeffrey W; Bao, Le (2017) Accounting for nonsampling error in estimates of HIV epidemic trends from antenatal clinic sentinel surveillance. AIDS 31 Suppl 1:S61-S68|