Abstract

Two hypothalamic peptides with corticotropin releasing activity, vasopressin and the newly characterized 41 amino acid ovine CRF have been found in hypophysial portal blood at concentrations sufficient to stimulate ACTH secretion. The goal of the research described in this proposal is to elucidate the relative role of these peptides in the regulation of ACTH by simultaneously measuring the hypophysial portal plasma concentration of vasopressin and CRF under conditions associated with changes in ACTH secretion. Included in the experimental models to be studied are adrenalectomy, stress, and short and long loop feedback. The ability to now measure vasopressin and CRF in portal blood should make it possible to rapidly advance our knowledge of the CNS control of pituitary-adrenal function and should make a major contribution to the understanding of the homeostatic mechanisms involved in the response to stress.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
5R01AM032517-03
Application #
3152549
Study Section
Endocrinology Study Section (END)
Project Start
1983-09-15
Project End
1986-07-15
Budget Start
1985-09-01
Budget End
1986-07-15
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Donjacour, A A; Rosales, A; Higgins, S J et al. (1990) Characterization of antibodies to androgen-dependent secretory proteins of the mouse dorsolateral prostate. Endocrinology 126:1343-54
Cheung, C Y; Gibbs, D M; Brace, R A (1987) Atrial natriuretic factor in maternal and fetal sheep. Am J Physiol 252:E279-82
Gibbs, D M (1987) Noncalcium-dependent modulation of in vitro atrial natriuretic factor release by extracellular osmolality. Endocrinology 120:194-7
Gibbs, D M (1986) Oxytocin inhibits ACTH and peripheral catecholamine secretion in the urethane-anesthetized rat. Regul Pept 14:125-32
Gibbs, D M (1986) Stress-specific modulation of ACTH secretion by oxytocin. Neuroendocrinology 42:456-8
Gibbs, D M (1986) Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review. Psychoneuroendocrinology 11:131-9
Suh, B Y; Liu, J H; Rasmussen, D D et al. (1986) Role of oxytocin in the modulation of ACTH release in women. Neuroendocrinology 44:309-13
Perkins, S N; Evans, W S; Thorner, M O et al. (1985) Beta-adrenergic binding and secretory responses of the anterior pituitary. Endocrinology 117:1818-25
Gibbs, D M (1985) Measurement of hypothalamic corticotropin-releasing factors in hypophyseal portal blood. Fed Proc 44:203-6
Gibbs, D M (1985) Immunoneutralization of oxytocin attenuates stress-induced corticotropin secretion in the rat. Regul Pept 12:273-7

Showing the most recent 10 out of 13 publications