Total knee replacement is the most common total joint procedure in the United States, and the number of procedures has grown dramatically over the past two decades to over the 580,000 per year. Despite the general success of cemented total knee replacement, aseptic loosening requiring a revision surgery is still common, particularly for younger and more active patients. New pilot data obtained from cemented tibial tray components following in vivo service show that there is extensive resorption of trabecular bone that interlocks with cement under the tibial tray and that this resorption may occur within the first few years following implantation. The working hypothesis is there is an early loss of mechanical micro-interlock between the cement and bone following implantation and this results in a loss of functional strength of the tibial tray component. In clinical practice, loss of interlck could cause an increased risk of component migration and aseptic loosening, particularly for high demand patients. The goal of this research program is to achieve arthroplasties that function successfully for the lifetime of the patient without the need for revision. In this competitive renewal the applicants leverage the experience gained from the current funding cycle on fixation of total hip replacement following in vivo service and combine these with new approaches to assess and address loosening issues associated with knee replacements.
The specific aims are to (1) discover the temporal and spatial changes to the fixation morphology following in vivo service with particular attention to short term in vivo service;(2) determine th influence of these morphological changes on the structure/mechanical function relationship for the fixation interfaces and complete tibial tray constructs;(3) explore potential mechanical mechanisms responsible for trabecular bone resorption from interdigitated cement-bone regions;(4) determine the loss of functional strength of whole constructs due to in vivo service;and (5) perform translational biomechanics studies to mitigate bone loss through improved load transfer to the underside of the tibial tray (termed a type A scenario) using targeted design changes. If trabecular bone loss under tray cannot be prevented (termed a type B scenario), determine amount of distal fixation needed to prevent loosening for 'normal'and 'high demand'patients. A synergistic combination of experimental and computational methods is used to address these aims.

Public Health Relevance

Loss of fixation between implant and bone in total knee replacement remains the most common cause of early loosening which leads to an additional surgery and replacement of the loose component. This work investigates how the bone that interlocks with the cement for fixation changes after placement of the joint replacement at time of surgery. The goal of this project is to find new approaches to prevent loss of fixation through changes in implant design and surgical technique.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042017-16
Application #
8534836
Study Section
Skeletal Biology Structure and Regeneration Study Section (SBSR)
Program Officer
Panagis, James S
Project Start
1996-07-15
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
16
Fiscal Year
2013
Total Cost
$372,788
Indirect Cost
$105,431
Name
Upstate Medical University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210
Miller, Mark A; Terbush, Matthew J; Goodheart, Jacklyn R et al. (2014) Increased initial cement-bone interlock correlates with reduced total knee arthroplasty micro-motion following in vivo service. J Biomech 47:2460-6
Goodheart, Jacklyn R; Miller, Mark A; Mann, Kenneth A (2014) In vivo loss of cement-bone interlock reduces fixation strength in total knee arthroplasties. J Orthop Res 32:1052-60
Mann, Kenneth A; Miller, Mark A; Goodheart, Jacklyn R et al. (2014) Peri-implant bone strains and micro-motion following in vivo service: a postmortem retrieval study of 22 tibial components from total knee replacements. J Orthop Res 32:355-61
Oest, Megan E; Miller, Mark A; Howard, Karen I et al. (2014) A novel in vitro loading system to produce supraphysiologic oscillatory fluid shear stress. J Biomech 47:518-25
Miller, Mark A; Goodheart, Jacklyn R; Izant, Timothy H et al. (2014) Loss of cement-bone interlock in retrieved tibial components from total knee arthroplasties. Clin Orthop Relat Res 472:304-13
Howard, Karen I; Miller, Mark A; Damron, Timothy A et al. (2014) The distribution of implant fixation for femoral components of TKA: a postmortem retrieval study. J Arthroplasty 29:1863-70
Mann, Kenneth A; Miller, Mark A (2013) Fluid-structure interactions in micro-interlocked regions of the cement-bone interface. Comput Methods Biomech Biomed Engin :
Mann, Kenneth A; Miller, Mark A; Costa, Peter A et al. (2012) Interface micromotion of uncemented femoral components from postmortem retrieved total hip replacements. J Arthroplasty 27:238-245.e1
Waanders, Daan; Janssen, Dennis; Mann, Kenneth A et al. (2011) The behavior of the micro-mechanical cement-bone interface affects the cement failure in total hip replacement. J Biomech 44:228-34
Race, A; Miller, M A; Izant, T H et al. (2011) Direct evidence of "damage accumulation" in cement mantles surrounding femoral hip stems retrieved at autopsy: cement damage correlates with duration of use and BMI. J Biomech 44:2345-50

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