Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042666-02
Application #
2082073
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1995-01-09
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Christner, Paul J; Gentiletti, Julieta; Peters, Josephine et al. (2006) Collagen dysregulation in the dermis of the Sagg/+ mouse: a loose skin model. J Invest Dermatol 126:595-602
Christner, P J; Ayitey, S (2006) Extracellular matrix containing mutated fibrillin-1 (Fbn1) down regulates Col1a1, Col1a2, Col3a1, Col5a1, and Col5a2 mRNA levels in Tsk/+ and Tsk/Tsk embryonic fibroblasts. Amino Acids 30:445-51
Gentiletti, Julieta; McCloskey, Laura J; Artlett, Carol M et al. (2005) Demonstration of autoimmunity in the tight skin-2 mouse: a model for scleroderma. J Immunol 175:2418-26
Christner, Paul J; Jimenez, Sergio A (2004) Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches. Curr Opin Rheumatol 16:746-52
Christner, Paul J; Yufit, Tatyana; Peters, Josephine et al. (2003) Transcriptional activation of alpha 1(III) procollagen gene in Tsk2/+ dermal fibroblasts. Biochem Biophys Res Commun 303:406-12
Christner, P J; Artlett, C M; Conway, R F et al. (2000) Increased numbers of microchimeric cells of fetal origin are associated with dermal fibrosis in mice following injection of vinyl chloride. Arthritis Rheum 43:2598-605
Sgonc, R; Dietrich, H; Sieberer, C et al. (1999) Lack of endothelial cell apoptosis in the dermis of tight skin 1 and tight skin 2 mice. Arthritis Rheum 42:581-4
Wooley, P H; Sud, S; Langendorfer, A et al. (1998) T cells infiltrating the skin of Tsk2 scleroderma-like mice exhibit T cell receptor bias. Autoimmunity 27:91-8
Christner, P J; Hitraya, E G; Peters, J et al. (1998) Transcriptional activation of the alpha1(I) procollagen gene and up-regulation of alpha1(I) and alpha1(III) procollagen messenger RNA in dermal fibroblasts from tight skin 2 mice. Arthritis Rheum 41:2132-42