Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042927-03
Application #
2082475
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1994-07-15
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Destaing, Olivier; Ferguson, Shawn M; Grichine, Alexei et al. (2013) Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes. PLoS One 8:e77956
Purev, Enkhtsetseg; Neff, Lynn; Horne, William C et al. (2009) c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes. Mol Biol Cell 20:4021-30
Bruzzaniti, Angela; Neff, Lynn; Sandoval, Amanda et al. (2009) Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts. Mol Cell Biol 29:3644-56
Destaing, Olivier; Sanjay, Archana; Itzstein, Cecile et al. (2008) The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. Mol Biol Cell 19:394-404
Li, Lei; Hisamoto, Koji; Kim, Kyung Hee et al. (2007) Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A 104:16468-73
Gil-Henn, Hava; Destaing, Olivier; Sims, Natalie A et al. (2007) Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol 178:1053-64
Bruzzaniti, Angela; Baron, Roland (2006) Molecular regulation of osteoclast activity. Rev Endocr Metab Disord 7:123-39
Aoki, Kazuhiro; Saito, Hiroaki; Itzstein, Cecile et al. (2006) A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest 116:1525-34
Sanjay, Archana; Miyazaki, Tsuyoshi; Itzstein, Cecile et al. (2006) Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl. FEBS J 273:5442-56
Bruzzaniti, Angela; Neff, Lynn; Sanjay, Archana et al. (2005) Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Mol Biol Cell 16:3301-13

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