Fibromyalgia Syndrome is a disabling musculo-skeletal disorder of unknown etiology. A number of clinical features of fibromyalgia resemble those seen in patients with hypoadrenalism, or during steroid withdrawal, including fatigue, muscle and joint pain, depression, and impaired sleep and cognitive function. The similarity of symptoms has led us and others to hypothesize that there is relative or absolute adrenal insufficiency in fibromyalgia. Several preliminary reports indicate decreased adrenal function in fibromyalgia, and similar hypotheses have recently been postulated in patients with Chronic Fatigue Syndrome (CFS), a syndrome with many clinical similarities to fibromyalgia. In this study, we propose to test the hypothesis that patients with fibromyalgia have inappropriately low basal adrenocortical activity and to determine the site or sites of abnormality that account for this difference. Studies will compare the activity of the hypothalamic- pituitary-adrenal (HPA) axis in patients with fibromyalgia with HPA axis activity in matched normal healthy subjects and in patients with CFS. In these studies we will determine the circadian and pulsatile secretion of ACTH and adrenal steroids under basal conditions, determine the relationship between HPA axis activity and sleep disturbances, determine whether exacerbations in clinical symptomatology are associated with decreases in adrenocortical activity, and determine the responsiveness to specific stimuli of the adrenal, the pituitary and the hypothalamic- pituitary portions of the HPA axis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR043130-02
Application #
2082745
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1994-09-25
Project End
1997-05-31
Budget Start
1995-09-01
Budget End
1996-05-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Vijayan, Sujith; Klerman, Elizabeth B; Adler, Gail K et al. (2015) Thalamic mechanisms underlying alpha-delta sleep with implications for fibromyalgia. J Neurophysiol 114:1923-30
Faghih, Rose T; Dahleh, Munther A; Adler, Gail K et al. (2015) Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. IEEE Trans Biomed Eng 62:2379-88
Faghih, Rose T; Dahleh, Munther A; Adler, Gail K et al. (2014) Deconvolution of serum cortisol levels by using compressed sensing. PLoS One 9:e85204
Dean 2nd, Dennis A; Adler, Gail K; Nguyen, David P et al. (2014) Biological time series analysis using a context free language: applicability to pulsatile hormone data. PLoS One 9:e104087
Kubzansky, Laura D; Adler, Gail K (2010) Aldosterone: a forgotten mediator of the relationship between psychological stress and heart disease. Neurosci Biobehav Rev 34:80-6
Adler, G K; Bonyhay, I; Curren, V et al. (2010) Hypoglycaemia increases aldosterone in a dose-dependent fashion. Diabet Med 27:1250-5
Togo, Fumiharu; Natelson, Benjamin H; Adler, Gail K et al. (2009) Plasma cytokine fluctuations over time in healthy controls and patients with fibromyalgia. Exp Biol Med (Maywood) 234:232-40
Szmuilowicz, Emily D; Adler, Gail K; Ricchiuti, Vincent et al. (2007) Relationships between endogenous sex hormone concentrations and vascular function in postmenopausal women. J Clin Endocrinol Metab 92:4738-41
Szmuilowicz, Emily D; Adler, Gail K; Williams, Jonathan S et al. (2006) Relationship between aldosterone and progesterone in the human menstrual cycle. J Clin Endocrinol Metab 91:3981-7
McCall-Hosenfeld, Jennifer S; Goldenberg, Don L; Hurwitz, Shelley et al. (2003) Growth hormone and insulin-like growth factor-1 concentrations in women with fibromyalgia. J Rheumatol 30:809-14

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