Collagen is the most abundant protein in vertebrates, occurring in virtually every tissue. Collagen abnormalities are associated with a wide variety of human diseases. The objective of the proposed research is to obtain an atomic-level understanding of collagen structure and stability in vitro and in vivo. The results could ultimately lead to the creation of collagen mimics with important therapeutic applications.
| Ellison, Aubrey J; Raines, Ronald T (2018) A pendant peptide endows a sunscreen with water-resistance. Org Biomol Chem 16:7139-7142 |
| Vasta, James D; Raines, Ronald T (2018) Collagen Prolyl 4-Hydroxylase as a Therapeutic Target. J Med Chem : |
| Newberry, Robert W; Raines, Ronald T (2017) The n??* Interaction. Acc Chem Res 50:1838-1846 |
| Newberry, Robert W; Raines, Ronald T (2017) 4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins. Top Heterocycl Chem 48:1-25 |
| Vasta, James D; Choudhary, Amit; Jensen, Katrina H et al. (2017) Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond. Biochemistry 56:219-227 |
| Newberry, Robert W; Raines, Ronald T (2016) A prevalent intraresidue hydrogen bond stabilizes proteins. Nat Chem Biol 12:1084-1088 |
| Newberry, R W; Raines, R T (2016) Crystal structure of N-(3-oxo-butano-yl)-l-homoserine lactone. Acta Crystallogr E Crystallogr Commun 72:136-9 |
| Vasta, James D; Andersen, Kristen A; Deck, Kathryn M et al. (2016) Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells. ACS Chem Biol 11:193-9 |
| Tanrikulu, I Caglar; Forticaux, Audrey; Jin, Song et al. (2016) Peptide tessellation yields micrometre-scale collagen triple helices. Nat Chem 8:1008-1014 |
| Arnold, Ulrich; Raines, Ronald T (2016) Replacing a single atom accelerates the folding of a protein and increases its thermostability. Org Biomol Chem 14:6780-5 |
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