Abstract

The hypotheses will be addressed by the following specific aims: 1] To determine if myofibrillar mRNA abundance regulates skeletal muscle protein synthesis in the early postnatal period, and if variations in MRF expression in the early postnatal period modulate rates of myofibrillar protein synthesis, 2] a) To determine whether the enhanced skeletal muscle protein and DNA accretion induced by muscle-specific overexpression of IGF-I is impaired when MRF function is inhibited, b) To determine whether tissue IGF-I concentrations regulate skeletal muscle protein synthesis by increasing the sensitivity of muscle protein synthesis to insulin, 3] To compare the protein synthetic responses of immature versus mature skeletal muscle to nutritional rehabilitation in the presence of variable levels of MRF activity and muscle IGF-I abundance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR046308-04
Application #
6606183
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Nuckolls, Glen H
Project Start
2000-08-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$290,030
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Manjarín, Rodrigo; Columbus, Daniel A; Solis, Jessica et al. (2018) Short- and long-term effects of leucine and branched-chain amino acid supplementation of a protein- and energy-reduced diet on muscle protein metabolism in neonatal pigs. Amino Acids 50:943-959
Crossland, Randy F; Balasa, Alfred; Ramakrishnan, Rajesh et al. (2017) Chronic Maternal Low-Protein Diet in Mice Affects Anxiety, Night-Time Energy Expenditure and Sleep Patterns, but Not Circadian Rhythm in Male Offspring. PLoS One 12:e0170127
Hennebry, Alexander; Oldham, Jenny; Shavlakadze, Tea et al. (2017) IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. J Endocrinol 234:187-200
Gokulakrishnan, Ganga; Chang, Xiaoyan; Fleischmann, Ryan et al. (2017) Precocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat. J Endocrinol 232:561-572
Manjarín, Rodrigo; Columbus, Daniel A; Suryawan, Agus et al. (2016) Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs. Amino Acids 48:257-267
Eclarinal, Jesse D; Zhu, Shaoyu; Baker, Maria S et al. (2016) Maternal exercise during pregnancy promotes physical activity in adult offspring. FASEB J 30:2541-8
Columbus, Daniel A; Fiorotto, Marta L; Davis, Teresa A (2015) Leucine is a major regulator of muscle protein synthesis in neonates. Amino Acids 47:259-70
Davis, Teresa A; Fiorotto, Marta L; Suryawan, Agus (2015) Bolus vs. continuous feeding to optimize anabolism in neonates. Curr Opin Clin Nutr Metab Care 18:102-8
Fiorotto, Marta L; Davis, Teresa A; Sosa, Horacio A et al. (2014) Ribosome abundance regulates the recovery of skeletal muscle protein mass upon recuperation from postnatal undernutrition in mice. J Physiol 592:5269-86
Li, Ge; Kohorst, John J; Zhang, Wenjuan et al. (2013) Early postnatal nutrition determines adult physical activity and energy expenditure in female mice. Diabetes 62:2773-83

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