Damage accumulation in tendons and tendon tears are a major source of musculoskeletal disability, afflicting the entire spectrum of society. Despite the importance of these problems, clinicians have little scientific basis for treatment recommendations because mechanisms whereby exercise may improve tendon homeostasis and resistance to injury, mechanisms responsible for the poor healing of fatigue damaged tendons, and the effect of activity on the healing of repaired diseased tendons are unknown. Previous studies have investigated the effects of exercise and laceration, but only in healthy tendon. We have developed and extensively characterized an in vivo model of fatigue damage accumulation in the rat patellar tendon, and now propose to study the response of fatigue damaged tendon to exercise and/or laceration. These studies, using this clinically relevant model of diseased tendons, will provide the foundation for novel and improved treatment strategies.

Public Health Relevance

The major goal of this project is to explore the effect of tendon overuse damage on the response of tenocytes to exercise and laceration. Successful completion of the proposed studies will provide the foundation for novel and improved treatment strategies for tendon injury.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR052743-07
Application #
8323901
Study Section
Skeletal Biology Structure and Regeneration Study Section (SBSR)
Program Officer
Tyree, Bernadette
Project Start
2005-09-01
Project End
2016-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
7
Fiscal Year
2012
Total Cost
$401,327
Indirect Cost
$162,464
Name
Icahn School of Medicine at Mount Sinai
Department
Orthopedics
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Andarawis-Puri, Nelly; Philip, Anaya; Laudier, Damien et al. (2014) Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters. J Orthop Res 32:1097-103
Sereysky, Jedd B; Flatow, Evan L; Andarawis-Puri, Nelly (2013) Musculoskeletal regeneration and its implications for the treatment of tendinopathy. Int J Exp Pathol 94:293-303
Ros, Stephen J; Andarawis-Puri, Nelly; Flatow, Evan L (2013) Tendon extracellular matrix damage detection and quantification using automated edge detection analysis. J Biomech 46:2844-7
Sun, Hui B; Zhao, Liming; Tanaka, Shigeo et al. (2012) Moderate joint loading reduces degenerative actions of matrix metalloproteinases in the articular cartilage of mouse ulnae. Connect Tissue Res 53:180-6
Andarawis-Puri, Nelly; Sereysky, Jedd B; Sun, Hui B et al. (2012) Molecular response of the patellar tendon to fatigue loading explained in the context of the initial induced damage and number of fatigue loading cycles. J Orthop Res 30:1327-34
Andarawis-Puri, Nelly; Sereysky, Jedd B; Jepsen, Karl J et al. (2012) The relationships between cyclic fatigue loading, changes in initial mechanical properties, and the in vivo temporal mechanical response of the rat patellar tendon. J Biomech 45:59-65
Sereysky, Jedd B; Andarawis-Puri, Nelly; Jepsen, Karl J et al. (2012) Structural and mechanical effects of in vivo fatigue damage induction on murine tendon. J Orthop Res 30:965-72
Lee, Jonathan Y; Zhou, Zuping; Taub, Peter J et al. (2011) BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PLoS One 6:e17531
Leong, Daniel J; Sun, Hui B (2011) Events in articular chondrocytes with aging. Curr Osteoporos Rep 9:196-201
Leong, Daniel J; Hardin, John A; Cobelli, Neil J et al. (2011) Mechanotransduction and cartilage integrity. Ann N Y Acad Sci 1240:32-7

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