Acetabular dysplasia may be the leading cause of premature osteoarthritis (OA) of the hip. However, the relationship between the altered geometry associated with dysplasia and the resulting stresses in and around the joint is poorly understood. The overall hypothesis of this study is that acetabular dysplasia causes alterations in hip joint biomechanics, which predispose the joint to cartilage degeneration. Subject-specific, three-dimensional finite element modeling techniques will be developed and validated to study hip joint biomechanics. Then, using three patient populations (normal, traditional dysplastic and retroverted dysplastic), patient-specific finite element models will be used to determine stresses in and around the hip joint during simulated walking, stair-climbing and descending stairs. Patient-specific hip joint computational models also have a number of potential longer-term uses and benefits, including patient-specific approaches to treatment, and prediction of the long-term success rate of corrective surgeries based on pre- and post-operative mechanics. The methods to be developed and validated in this research can be directly applied to quantify changes in mechanical loading due to surgical intervention, allowing us to assess the efficacy of different approaches to osteotomy on a patient-specific basis. We also envision using these techniques for longer-term prospective studies, to correlate surgical correction with changes in mechanical loading and long-term outcome. Currently, the status quo is that long-term success is measured by avoidance of a total hip arthroplasty and is not correlated with any preoperative variable other than the relatively crude measurements made on an anteroposterior radiograph. Relevance to Public Health: Many orthopaedic surgeons are unaware of multiple facets of the hip dysplasia diagnosis and their potential implications for joint degeneration. Recognizing the mechanical consequences of different and often subtle forms of dysplasia allows earlier identification of """"""""at risk'hips so that earlier treatment can be initiated, hopefully delaying the need for total hip athroplasty. This research will immediately help to delineate the true spectrum of this three-dimensional pathology by quantifying stress transfer in the hip joint using patient specific computational models.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR053344-05
Application #
8088239
Study Section
Skeletal Biology Structure and Regeneration Study Section (SBSR)
Program Officer
Panagis, James S
Project Start
2007-07-01
Project End
2013-12-31
Budget Start
2011-07-01
Budget End
2013-12-31
Support Year
5
Fiscal Year
2011
Total Cost
$239,842
Indirect Cost
Name
University of Utah
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Knight, Spencer J; Abraham, Christine L; Peters, Christopher L et al. (2017) Changes in chondrolabral mechanics, coverage, and congruency following peri-acetabular osteotomy for treatment of acetabular retroversion: A patient-specific finite element study. J Orthop Res 35:2567-2576
Klennert, Brenden J; Ellis, Benjamin J; Maak, Travis G et al. (2017) The mechanics of focal chondral defects in the hip. J Biomech 52:31-37
Maas, Steve A; Ellis, Benjamin J; Rawlins, David S et al. (2016) Finite element simulation of articular contact mechanics with quadratic tetrahedral elements. J Biomech 49:659-67
Abraham, Christine L; Bangerter, Neal K; McGavin, Lance S et al. (2015) Accuracy of 3D dual echo steady state (DESS) MR arthrography to quantify acetabular cartilage thickness. J Magn Reson Imaging 42:1329-38
Ateshian, Gerard A; Henak, Corinne R; Weiss, Jeffrey A (2015) Toward patient-specific articular contact mechanics. J Biomech 48:779-86
Henak, Corinne R; Ateshian, Gerard A; Weiss, Jeffrey A (2014) Finite element prediction of transchondral stress and strain in the human hip. J Biomech Eng 136:021021
Henak, C R; Abraham, C L; Anderson, A E et al. (2014) Patient-specific analysis of cartilage and labrum mechanics in human hips with acetabular dysplasia. Osteoarthritis Cartilage 22:210-7
Harris, Michael D; Kapron, Ashley L; Peters, Christopher L et al. (2014) Correlations between the alpha angle and femoral head asphericity: Implications and recommendations for the diagnosis of cam femoroacetabular impingement. Eur J Radiol 83:788-96
Henak, C R; Abraham, C L; Peters, C L et al. (2014) Computed tomography arthrography with traction in the human hip for three-dimensional reconstruction of cartilage and the acetabular labrum. Clin Radiol 69:e381-91
Kapron, Ashley L; Aoki, Stephen K; Peters, Christopher L et al. (2014) Accuracy and feasibility of dual fluoroscopy and model-based tracking to quantify in vivo hip kinematics during clinical exams. J Appl Biomech 30:461-70

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