The long-term goal of this proposed project is to better clarify the role of both individual and community social determinants with health outcomes in 4337 non-Hispanic African-Americans and non-Hispanic Caucasians with OA. This will be accomplished in a unique, prospective, population-based study of knee and hip OA in Johnston County, a predominantly rural county in North Carolina. This goal will be accomplished using multi- methodology through the following aims: 1) to determine whether there is an independent association between community and individual SES with knee and hip OA prevalence;2) to determine whether there is an independent association between community and individual SES with arthritis severity and progression;3) to determine whether there is an independent association between community and individual SES with disability;4) to determine whether there is an independent association between SES (community and individual) and mortality;5) to develop a measure of observational assessment for community health characteristics and develop a scale to assess participants'perceptions of these characteristics;6) to test hypothesized mediators of relationships between individual and community SES with knee and hip OA prevalence and outcomes.

Public Health Relevance

The gap in health outcomes is multifactorial, incompletely understood, and potentially difficult to redress in its entirety. However, a better understanding of the individual and community factors that influence health outcomes in racial and ethnic groups will provide an invaluable foundation for designing interventions and creating policies to reduce these gaps.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR053989-05
Application #
8242030
Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Lester, Gayle E
Project Start
2008-04-03
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$305,268
Indirect Cost
$96,180
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Cleveland, Rebecca J; Luong, My-Linh N; Knight, Joshua B et al. (2013) Independent associations of socioeconomic factors with disability and pain in adults with knee osteoarthritis. BMC Musculoskelet Disord 14:297
Cleveland, Rebecca J; Schwartz, Todd A; Prizer, Lindsay P et al. (2013) Associations of educational attainment, occupation, and community poverty with hip osteoarthritis. Arthritis Care Res (Hoboken) 65:954-61
Nelson, Amanda E; Renner, Jordan B; Shi, Xiaoyan A et al. (2010) Cross-sectional comparison of extended anteroposterior and posteroanterior fixed flexion positioning to assess radiographic osteoarthritis at the knee: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken) 62:1342-5