This study investigates an expanded paradigm to improve health outcomes for adults with knee osteoarthritis (OA), through changes in the low end of the physical activity spectrum where much of the knee OA population resides. Our recent study found almost half of adults with knee OA were inactive, as defined by the US Department of Health and Human Services (DHHS) (i.e., no sustained 10 minute periods of moderate-to- vigorous intensity physical activity during a week) based on objective accelerometer measurement of physical activity. It is these inactive people who will be the primary focus of this study. This renewal will investigate predictors and health outcomes related to transitions from and to physical inactivity. It will also to identify evidence-based physical activity metrics and thresholds needed to maintain function and reduce disability. The study builds on our current funded work from the Osteoarthritis Initiative (OAI), a prospective, observational, cohort study of adults with or at high risk for knee OA that encompasses the full spectrum of knee OA disease severity. This proposal will utilize valuable objective longitudinal physical activity data measure by accelerometer on a subsample from the OAI national cohort (n=2015) collected by the parent study to accomplish the following: Technical Aim. Process accelerometer output into usable physical activity measures and determine inactivity/activity transition status for each person.
Aim 1. Evaluate the relationship between a transition from inactivity to activity (T0 toT1) with initia and future changes in disability and function, controlling for baseline total activity, descriptive factors, and modifiable factors.
This aim i s relevant to clinical practice Aim 2. Examine among inactive adults at baseline the relationship between the change in total activity (T0 toT1) with initial and future changes in disability and function, controlling for baseline total activity, descriptive factors, and modifiable factors.
This aim i s relevant to the design of public health interventions.
Aim 3. Identify predictors of becoming inactive.
This aim i s relevant to public policy design.
Aim 4. Develop evidence-based physical activity metrics to predict short-term (T0 toT1) function and long- term (T0 toT2) disability outcomes among adults at high risk or with knee OA (both active and inactive at baseline).
This aim i s relevant to refining physical activity public health recommendations. Findings from this proposed study have important public health implications for the design of future physical activity intervention programs to improve quality of life among the 21 million U.S. adults who have knee OA.

Public Health Relevance

This study is built upon a strong scientific framework to evaluate the longitudinal relationship between changes in physical activity and health outcomes among adults with knee OA. The aims are designed to broaden the public health and clinical practice paradigm to promote better health for persons at the low end of the physical activity spectrum. Attainable evidence-based physical activity thresholds related to good function and preventing/reducing disability may provide realistic goals to promote increased physical activity, especially in people with arthritis who have pain and mobility problems.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01AR054155-07
Application #
8708493
Study Section
Neurological, Aging and Musculoskeletal Epidemiology Study Section (NAME)
Program Officer
Lester, Gayle E
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611
Dunlop, Dorothy D; Song, Jing; Arnston, Emily K et al. (2015) Sedentary time in US older adults associated with disability in activities of daily living independent of physical activity. J Phys Act Health 12:93-101
Lee, Jungwha; Chang, Rowland W; Ehrlich-Jones, Linda et al. (2015) Sedentary behavior and physical function: objective evidence from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken) 67:366-73
Sohn, M-W; Manheim, L M; Chang, R W et al. (2014) Sedentary behavior and blood pressure control among osteoarthritis initiative participants. Osteoarthritis Cartilage 22:1234-40
Dunlop, Dorothy D; Song, Jing; Semanik, Pamela A et al. (2014) Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: prospective cohort study. BMJ 348:g2472
Song, Jing; Hochberg, Marc C; Chang, Rowland W et al. (2013) Racial and ethnic differences in physical activity guidelines attainment among people at high risk of or having knee osteoarthritis. Arthritis Care Res (Hoboken) 65:195-202
Lee, Jungwha; Song, Jing; Hootman, Jennifer M et al. (2013) Obesity and other modifiable factors for physical inactivity measured by accelerometer in adults with knee osteoarthritis. Arthritis Care Res (Hoboken) 65:53-61
Feinglass, Joe; Song, Jing; Semanik, Pamela et al. (2012) Association of functional status with changes in physical activity: insights from a behavioral intervention for participants with arthritis. Arch Phys Med Rehabil 93:172-5
Dunlop, Dorothy D; Song, Jing; Semanik, Pamela A et al. (2011) Physical activity levels and functional performance in the osteoarthritis initiative: a graded relationship. Arthritis Rheum 63:127-36
Dunlop, Dorothy D; Song, Jing; Semanik, Pamela A et al. (2011) Objective physical activity measurement in the osteoarthritis initiative: Are guidelines being met? Arthritis Rheum 63:3372-82
Semanik, Pamela; Lee, Jungwha; Manheim, Larry et al. (2011) Relationship between accelerometer-based measures of physical activity and the Yale Physical Activity Survey in adults with arthritis. Arthritis Care Res (Hoboken) 63:1766-72

Showing the most recent 10 out of 13 publications