The anterior cruciate ligament (ACL) is one of the most commonly injured ligaments of the knee, with female athletes sustaining ACL injuries at a 2-8 fold greater rate compared to male athletes. An ACL injury can be devastating and significantly increases the athlete's risk for osteoarthritis long term. While many advances have been made in terms of surgical and rehabilitation treatments for ACL injured patients, long term outcome studies show that these patients are at a high risk for developing knee osteoarthritis 10-15 years after ACL injury regardless of the treatment. Currently, the mechanism of non-contact ACL injury is not well understood. In order to design successful ACL injury prevention programs and address the high rates of ACL injuries in the female athlete population, a better understanding of the non-contact ACL injury mechanism must be established. Both biomechanical data and video analyses indicate that increased abduction loads in the lower extremities may be associated with increased ACL strain and risk of injury. However, the medial collateral ligament (MCL) is considered to be the primary restraint against abduction stress in the knee joint. Clinicians and biomechanists are unable to explain why ACL ruptures without MCL injuries are significantly more common than combined ACL/MCL injuries. We hypothesize that coupled abduction and anterior knee joint loads near full knee extension will lead to disproportional increases in ACL strain relative to MCL strain and lead to ACL failure loads without concomitant MCL failure loads in female athletes. We propose to use a unique blend of the current methods used to investigate ACL injury mechanisms in order to gain an in depth understanding of knee ligament biomechanics during high knee loading conditions. Specifically, we aim to determine the mechanical responses of the ACL and MCL to loads using cadaveric testing, computer mathematical modeling, and three-dimensional motion analysis. Identifying ACL injury mechanisms may help us develop ACL injury prevention programs that would allow many athletes to receive the health benefits of sports participation and avoid the long term sequelae of disability associated with knee osteoarthritis.

Public Health Relevance

Relevance to Public Health:An anterior cruciate ligament (ACL) injury can be devastating and places an athlete at a high risk of developing osteoarthritis long term. Unfortunately, surgical intervention does not change the odds of developing knee osteoarthritis after injury. We utilize biomechanical methods to identify mechanisms of ACL injury in order to develop effective interventions to prevent ACL injury.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR056259-04
Application #
8284418
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Panagis, James S
Project Start
2009-05-15
Project End
2013-09-15
Budget Start
2012-05-01
Budget End
2013-09-15
Support Year
4
Fiscal Year
2012
Total Cost
$416,997
Indirect Cost
$59,874
Name
Ohio State University
Department
Physiology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Bates, Nathaniel A; Myer, Gregory D; Hewett, Timothy E (2015) Prediction of kinematic and kinetic performance in a drop vertical jump with individual anthropometric factors in adolescent female athletes: implications for cadaveric investigations. Ann Biomed Eng 43:929-36
Hall, Randon; Barber Foss, Kim; Hewett, Timothy E et al. (2015) Sport specialization's association with an increased risk of developing anterior knee pain in adolescent female athletes. J Sport Rehabil 24:31-5
Myer, Gregory D; Ford, Kevin R; Di Stasi, Stephanie L et al. (2015) High knee abduction moments are common risk factors for patellofemoral pain (PFP) and anterior cruciate ligament (ACL) injury in girls: is PFP itself a predictor for subsequent ACL injury? Br J Sports Med 49:118-22
Bates, Nathaniel A; McPherson, April L; Rao, Marepalli B et al. (2014) Characteristics of inpatient anterior cruciate ligament reconstructions and concomitant injuries. Knee Surg Sports Traumatol Arthrosc :
Kiapour, Ata M; Kaul, Vikas; Kiapour, Ali et al. (2014) The Effect of Ligament Modeling Technique on Knee Joint Kinematics: A Finite Element Study. Appl Math (Irvine) 4:91-97
Barber Foss, Kim D; Myer, Greg D; Hewett, Timothy E (2014) Epidemiology of basketball, soccer, and volleyball injuries in middle-school female athletes. Phys Sportsmed 42:146-53
Myer, Gregory D; Barber Foss, Kim D; Gupta, Resmi et al. (2014) Analysis of patient-reported anterior knee pain scale: implications for scale development in children and adolescents. Knee Surg Sports Traumatol Arthrosc :
Roewer, Benjamin D; Ford, Kevin R; Myer, Gregory D et al. (2014) The 'impact' of force filtering cut-off frequency on the peak knee abduction moment during landing: artefact or 'artifiction'? Br J Sports Med 48:464-8
Sugimoto, Dai; Myer, Gregory D; Foss, Kim D Barber et al. (2014) Dosage effects of neuromuscular training intervention to reduce anterior cruciate ligament injuries in female athletes: meta- and sub-group analyses. Sports Med 44:551-62
Patel, Sonika A; Hageman, Jason; Quatman, Carmen E et al. (2014) Prevalence and location of bone bruises associated with anterior cruciate ligament injury and implications for mechanism of injury: a systematic review. Sports Med 44:281-93

Showing the most recent 10 out of 68 publications