Chronic soft-tissue (or myofascial) pain is a significant public health problem. Despite its high prevalence, the underlying mechanisms are poorly understood. In particular, very little is known about the pathophysiology and soft tissue environment of a myofascial trigger point (MTrP). MTrPs are palpable, localized painful nodules in a taut band of skeletal muscle that are a characteristic finding in myofascial pain syndrome (MPS). MTrPs are associated with spontaneous referred pain in symptomatic patients, and are the target for current management strategies for MPS, such as dry needle therapy. Recently, our research group has developed new ultrasound imaging methods to visualize and characterize the physiology and physical properties of the MTrPs and their surrounding soft tissue;and microanalytic techniques to assay the local biochemical milieu. These innovative methodological advances provide a unique opportunity to integrate the physical, physiological and biochemical findings to achieve a more comprehensive understanding of the abnormalities associated with MTrPs (e.g., muscle, fascia, blood vessels);and to correlate these findings with clinical assessments to better understand the role of MTrPs in chronic pain. Our ultimate goal is to develop a working model of the underlying mechanisms of MTrPs and translate the findings to objective clinical outcome measures using office-based technology.
The specific aims of the project are: 1) To determine the mechanical tissue properties, vascular physiology and biochemical milieu of the affected soft tissue neighborhood of active MTrPs in patients with chronic neck pain compared to asymptomatic control subjects with/without palpable MTrPs;and 2) To determine the effect of a physical perturbation caused by dry needle therapy, a widely accepted method of treatment, on the soft tissue environment and biochemical milieu of active MTrPs in symptomatic subjects. Our working hypothesis is that MTrPs are sites of muscle injury where local biochemical changes lead to sustained muscle contracture, compression of blood vessels and a local energy crisis that causes tissue hypoxia. This condition perpetuates the release of inflammatory cytokines and nociceptive (pain-inducing) substances. To test this hypothesis, we will correlate ultrasound imaging scores, analyte levels and functional clinical measures in our specific aims. To translate these findings into clinical outcome measures that can be used in an office-based setting, we will adapt a reliable and inexpensive 3D Tactile Imaging instrument for quantifying mechanical soft tissue changes associated with MTrPs.

Public Health Relevance

Chronic pain is a significant public health concern. This proposal aims to identify anatomical and physiological abnormalities of muscle, fascia and blood flow in painful areas of the trapezius and neck associated with myofascial trigger points (MTrPs), which are a characteristic finding in myofascial pain syndrome (MPS). Demonstrating which tissues are involved (e.g., muscle, fascia, vessels), and which biochemicals are abnormal in MTrPs, will help develop appropriate preventive and therapeutic strategies, establish diagnostic criteria and potential outcome measures that can be used in treatment trials. Our approach would also be broadly applicable to elucidating the underlying mechanisms in other chronic musculoskeletal pain disorders, such low back pain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR057348-02
Application #
8041042
Study Section
Special Emphasis Panel (ZRG1-CFS-M (90))
Program Officer
Nuckolls, Glen H
Project Start
2010-04-01
Project End
2014-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
2
Fiscal Year
2011
Total Cost
$424,212
Indirect Cost
Name
George Mason University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
077817450
City
Fairfax
State
VA
Country
United States
Zip Code
22030
Gerber, Lynn H; Sikdar, Siddhartha; Aredo, Jacqueline V et al. (2017) Beneficial Effects of Dry Needling for Treatment of Chronic Myofascial Pain Persist for 6 Weeks After Treatment Completion. PM R 9:105-112
Turo, Diego; Otto, Paul; Hossain, Murad et al. (2015) Novel Use of Ultrasound Elastography to Quantify Muscle Tissue Changes After Dry Needling of Myofascial Trigger Points in Patients With Chronic Myofascial Pain. J Ultrasound Med 34:2149-61
Shah, Jay P; Thaker, Nikki; Heimur, Juliana et al. (2015) Myofascial Trigger Points Then and Now: A Historical and Scientific Perspective. PM R 7:746-761
Gerber, Lynn H; Shah, Jay; Rosenberger, William et al. (2015) Dry Needling Alters Trigger Points in the Upper Trapezius Muscle and Reduces Pain in Subjects With Chronic Myofascial Pain. PM R 7:711-718
Sikdar, Siddhartha; Wei, Qi; Cortes, Nelson (2014) Dynamic ultrasound imaging applications to quantify musculoskeletal function. Exerc Sport Sci Rev 42:126-35
Jafri, M Saleet; Kumar, Rashmi (2014) Modeling mitochondrial function and its role in disease. Prog Mol Biol Transl Sci 123:103-25
Turo, Diego; Otto, Paul; Shah, Jay P et al. (2013) Ultrasonic characterization of the upper trapezius muscle in patients with chronic neck pain. Ultrason Imaging 35:173-87
Gerber, Lynn H; Sikdar, Siddhartha; Armstrong, Katee et al. (2013) A systematic comparison between subjects with no pain and pain associated with active myofascial trigger points. PM R 5:931-8
Ballyns, Jeffrey J; Turo, Diego; Otto, Paul et al. (2012) Office-based elastographic technique for quantifying mechanical properties of skeletal muscle. J Ultrasound Med 31:1209-19
Turo, Diego; Otto, Paul; Shah, Jay P et al. (2012) Ultrasonic tissue characterization of the upper trapezius muscle in patients with myofascial pain syndrome. Conf Proc IEEE Eng Med Biol Soc 2012:4386-9

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