Osteoarthritis (OA) affects over 50 million Americans and has a substantial impact on the US economy and the health care system. Currently, there is no cure for this debilitating disease and the effective treatment is, at best, focused on symptomatic relief. The conventional MR techniques have shown promise for the identification of more subtle morphologic alterations as determined by cartilage volume, or surface fibrillation. However, they even the more innovative of these conventional techniques have not been consistent in predicting the knee OA progression. Therefore, there is a high demand for reliable, objective, non-invasive and quantitative imaging markers that identifies the risk population at early stage. The long-term goal of this proposal is to develop, implement, and characterize novel fluid suppressed-3D-23Na-UTE- techniques for in- vivo knee applications on an ultra high field system (7T). High-resolution, 23Na-(aggrecan) and 1H-(morphology, collagen) imaging of cartilage, along with improved imaging pulse sequences, image reconstructions, and visualization methods on an ultra-high field system (7T) will significantly impact the objective assessment of OA pathology. Specifically, this proposal will establish a powerful non-invasive imaging biomarker that is clinically useful for staging OA disease severity, predicting risk for progression and possibly serving as a future imaging biomarker for disease modifying therapies for OA. We will acquire high resolution sodium and proton MRI of age-and gender matched OA subjects in a longitudinal fashion to determine whether baseline combined risk profile can predict risk population for severe knee OA progression over 24 months period. Finally we determine the role of combined sodium and proton-MRI (1H-morphology, T2 mapping, and clinical scorings) findings at baseline in OA subjects in the prediction of knee OA progression over 24 months period. Once developed, validated in human knee joint then the sodium methodology will be translated on to a clinically relevant 3T platform. We believe that these studies will profoundly affect not only to diagnose OA in its earliest stages but also possibly identifies the risk population at early stage. We plan to address these goals via an interdisciplinary collaboration between Chemistry, Radiology, and Rheumatology to identify a risk profile that will be clinically useful to predict those at risk for disease progression.

Public Health Relevance

Osteoarthritis (OA) affects ~6% of the US adult population and ~12-13% of those age 60 and over. The current proposal will establish a powerful non-invasive imaging biomarker based on a fluid suppressed 3D-23Na- MRI that is clinically useful for assessment of early OA.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Research Project (R01)
Project #
Application #
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Lester, Gayle E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
Schools of Medicine
New York
United States
Zip Code
Sharafi, Azadeh; Chang, Gregory; Regatte, Ravinder R (2017) Bi-component T1? and T2 Relaxation Mapping of Skeletal Muscle In-Vivo. Sci Rep 7:14115
Chang, Gregory; Boone, Sean; Martel, Dimitri et al. (2017) MRI assessment of bone structure and microarchitecture. J Magn Reson Imaging 46:323-337
Sharafi, Azadeh; Chang, Gregory; Regatte, Ravinder R (2017) Biexponential T2 relaxation estimation of human knee cartilage in vivo at 3T. J Magn Reson Imaging :
Lee, Jae-Seung; Regatte, Ravinder R; Jerschow, Alexej (2017) Magnetization transfer in a partly deuterated lyotropic liquid crystal by single- and dual-frequency RF irradiations. J Magn Reson 281:141-150
Sharafi, Azadeh; Xia, Ding; Chang, Gregory et al. (2017) Biexponential T1? relaxation mapping of human knee cartilage in vivo at 3 T. NMR Biomed 30:
Xia, Ding; Lee, Jae-Seung; Regatte, Ravinder R (2017) Quadrupolar jump-and-return pulse sequence for fluid-suppressed sodium MRI of the knee joint at 7T. Magn Reson Med :
Naimon, Niels D; Walczyk, Jerzy; Babb, James S et al. (2017) A low-cost Mr compatible ergometer to assess post-exercise phosphocreatine recovery kinetics. MAGMA 30:281-289
Evgeny, Nimerovsky; Jerschow, Alexej (2016) Quadrupole sensitive pulse for signal filtering. J Magn Reson 265:153-63
Lee, Jae-Seung; Xia, Ding; Madelin, Guillaume et al. (2016) Sodium inversion recovery MRI on the knee joint at 7 T with an optimal control pulse. J Magn Reson 262:33-41
Lee, Jae-Seung; Regatte, Ravinder R; Jerschow, Alexej (2016) Bloch Equations for Proton Exchange Reactions in an Aqueous Solution. Concepts Magn Reson Part A Bridg Educ Res 45A:

Showing the most recent 10 out of 41 publications