CCR10 is a chemokine receptor. One of its ligand, CCL27, is predominantly expressed in the skin. The CCR10/ligand axis was suggested to play a role in directing migration and maintenance of CCR10-expressing T cells into the skin and has been implicated in many skin inflammatory diseases such as psoriasis and atopic dermatitis. However, the in vivo functional importance and mechanisms of CCR10 in regulating the cutaneous immune responses are still not clear. We have generated CCR10-knockout/EGFP-knockin mice and found that the CCR10-knockout mice have altered maintenance of skin-resident T cells and response to various skin antigen challenges. We propose to use these mouse models to study the functional mechanisms of CCR10 in regulating the skin T response and immune homeostasis.

Public Health Relevance

Public Health Narrative Many skin diseases such as inflammatory diseases and cancers are due to or involve the dysregulated immune response in the skin. Understanding how the immune system in the skin is regulated is critical to developing efficient treatment against the skin inflammation diseases and other dysfunctions. Findings from our proposed study on roles of an important skin-homing molecule CCR10 in regulating the skin T cell response will aid our understanding of molecular mechanisms regulating the skin immune response and development of therapeutic targets in treatment of the skin inflammation diseases.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
1R01AR064831-01A1
Application #
8697328
Study Section
Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section (HAI)
Program Officer
Cibotti, Ricardo
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Veterinary Sciences
Type
Earth Sciences/Resources
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802