Approximately 1 million people in the United States suffer from cartilage injuries every year. Traumatic knee injuries, often seen in otherwise healthy, active patients, commonly result in focal cartilage defects of the weight bearing articula surfaces of the knee. These defects can be sometimes asymptomatic, but swelling, pain and instability of the joint may occur. In addition, chronic degeneration of the cartilage due to alterd joint mechanics and loading may predispose the patient to the development of premature osteoarthritis (OA). Recent studies in the development of disease-modifying OA drugs (DMOADs) and cartilage repair therapies (bone marrow stimulation, tissue and cell-based techniques) are promising for the future management of disease. Ideally, any cartilage repair procedure would result in the regeneration of hyaline cartilage that has morphological, mechanical and biochemical properties similar to those of native cartilage. Therefore, there is a significant need for reliable, non-invasive MR biomarkers that could detect the early biochemical changes in cartilage even before morphological changes occur or in-vivo monitoring of cartilage repair procedures. The overarching goal of this proposal is to develop the hardware (dual tuned 23Na/1H knee coil array) and software (3D-FLORET-23Na- techniques) for in-vivo knee imaging on standard 3T clinical scanner. High- resolution, 23Na-(aggrecan) and 1H-(morphology, collagen) imaging of cartilage, along with improved RF coils, novel pulse sequences, image reconstructions, and visualization methods on 3T, will significantly improve the ability of clinicians to objectively monitor the efficacy of cartilage repair procedures. The proposed techniques developed will allow orthopaedic and trauma surgeons cutting-edge, powerful, noninvasive tools for diagnosis, pre-operative planning, and postoperative monitoring of cartilage repair through biochemical MRI. The outcome of this proposed study will significantly impact our ability for personalized treatment regimens and possibly prevent the development of premature OA.
The current proposal will establish a powerful non-invasive imaging biomarker based on development of new hardware (flexible dual tuned knee array) and software (3D-FLORET sodium - MRI) that is clinically useful for assessment of cartilage repair procedures.
|Sharafi, Azadeh; Chang, Gregory; Regatte, Ravinder R (2017) Bi-component T1? and T2 Relaxation Mapping of Skeletal Muscle In-Vivo. Sci Rep 7:14115|
|Chang, Gregory; Boone, Sean; Martel, Dimitri et al. (2017) MRI assessment of bone structure and microarchitecture. J Magn Reson Imaging 46:323-337|
|Sharafi, Azadeh; Chang, Gregory; Regatte, Ravinder R (2017) Biexponential T2 relaxation estimation of human knee cartilage in vivo at 3T. J Magn Reson Imaging :|
|Lee, Jae-Seung; Regatte, Ravinder R; Jerschow, Alexej (2017) Magnetization transfer in a partly deuterated lyotropic liquid crystal by single- and dual-frequency RF irradiations. J Magn Reson 281:141-150|
|Sharafi, Azadeh; Xia, Ding; Chang, Gregory et al. (2017) Biexponential T1? relaxation mapping of human knee cartilage in vivo at 3 T. NMR Biomed 30:|
|Xia, Ding; Lee, Jae-Seung; Regatte, Ravinder R (2017) Quadrupolar jump-and-return pulse sequence for fluid-suppressed sodium MRI of the knee joint at 7T. Magn Reson Med :|
|Lee, Jae-Seung; Xia, Ding; Madelin, Guillaume et al. (2016) Sodium inversion recovery MRI on the knee joint at 7 T with an optimal control pulse. J Magn Reson 262:33-41|
|Lee, Jae-Seung; Regatte, Ravinder R; Jerschow, Alexej (2016) Bloch Equations for Proton Exchange Reactions in an Aqueous Solution. Concepts Magn Reson Part A Bridg Educ Res 45A:|
|Brown, Ryan; Lakshmanan, Karthik; Madelin, Guillaume et al. (2016) A flexible nested sodium and proton coil array with wideband matching for knee cartilage MRI at 3T. Magn Reson Med 76:1325-34|