Emotion regulation is an essential component of mental health. Behavioral therapies have long acknowledged the importance of improving emotion regulation skills to promote resilience and to treat psychological disorders. Meditation is one mental training practice that has successfully been applied to cultivate skills in self-regulation of emotion, as it employs the un-biased present moment awareness of experiences. Several empirical studies have demonstrated that practice of meditation is associated with improvements in emotion regulation, mental health and well-being. However, little is known about the neurobiological mechanisms that underlie these improvements. The goal of this randomized, controlled, longitudinal study is to identify the neural mechanisms that underlie the improvements in emotion regulation associated with meditation practice. Ninety healthy but highly stressed participants will be randomly assigned to either an eight week Mindfulness-based stress reduction (MBSR) program or to an active control intervention that has been specifically designed to control for non-specific intervention effects associated with MBSR. In a pre-post design, participants will perform an emotion regulation task while functional MR images are acquired. We hypothesize that after the course, MBSR participants will show greater improvements in neural functions indicative of adaptive emotion regulation compared to participants of the control intervention. Furthermore, we will measure changes in gray matter morphometry in order to determine additional neural correlates of improved emotion regulation following MBSR. Our findings will help elucidate how meditation interventions exert their salubrious effects at the neurobiological level.

Public Health Relevance

This study will identify neural mechanisms associated with changes in emotion regulation following participation in Mindfulness-Based Stress Reduction (""""""""MBSR""""""""). The data generated will provide important insights into how this intervention works to reduce stress and enhance well-being.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Project (R01)
Project #
1R01AT006344-01
Application #
8025467
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Glowa, John R
Project Start
2011-07-01
Project End
2016-05-31
Budget Start
2011-07-01
Budget End
2012-05-31
Support Year
1
Fiscal Year
2011
Total Cost
$438,265
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
de Jong, Marasha; Peeters, Frenk; Gard, Tim et al. (2018) A Randomized Controlled Pilot Study on Mindfulness-Based Cognitive Therapy for Unipolar Depression in Patients With Chronic Pain. J Clin Psychiatry 79:
Van Dam, Nicholas T; van Vugt, Marieke K; Vago, David R et al. (2018) Mind the Hype: A Critical Evaluation and Prescriptive Agenda for Research on Mindfulness and Meditation. Perspect Psychol Sci 13:36-61
Greenberg, Jonathan; Shapero, Benjamin G; Mischoulon, David et al. (2017) Mindfulness-based cognitive therapy for depressed individuals improves suppression of irrelevant mental-sets. Eur Arch Psychiatry Clin Neurosci 267:277-282
de Jong, Marasha; Lazar, Sara W; Hug, Kiran et al. (2016) Effects of Mindfulness-Based Cognitive Therapy on Body Awareness in Patients with Chronic Pain and Comorbid Depression. Front Psychol 7:967
Hölzel, Britta K; Brunsch, Vincent; Gard, Tim et al. (2016) Mindfulness-Based Stress Reduction, Fear Conditioning, and The Uncinate Fasciculus: A Pilot Study. Front Behav Neurosci 10:124
Gard, Tim; Taquet, Maxime; Dixit, Rohan et al. (2015) Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls. Front Hum Neurosci 9:137
Gard, Tim; Taquet, Maxime; Dixit, Rohan et al. (2014) Fluid intelligence and brain functional organization in aging yoga and meditation practitioners. Front Aging Neurosci 6:76
Desbordes, Gaëlle; Gard, Tim; Hoge, Elizabeth A et al. (2014) Moving beyond Mindfulness: Defining Equanimity as an Outcome Measure in Meditation and Contemplative Research. Mindfulness (N Y) 2014:
Singleton, Omar; Hölzel, Britta K; Vangel, Mark et al. (2014) Change in Brainstem Gray Matter Concentration Following a Mindfulness-Based Intervention is Correlated with Improvement in Psychological Well-Being. Front Hum Neurosci 8:33
Gard, Tim; Hölzel, Britta K; Lazar, Sara W (2014) The potential effects of meditation on age-related cognitive decline: a systematic review. Ann N Y Acad Sci 1307:89-103

Showing the most recent 10 out of 16 publications