Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA016265-19S1
Application #
2086449
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1977-04-01
Project End
1995-11-30
Budget Start
1993-12-01
Budget End
1994-11-30
Support Year
19
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Pharmacology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Halberg, Richard B; Larsen, Michele Campaigne; Elmergreen, Tammy L et al. (2008) Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates. Cancer Res 68:7394-402
Zheng, Wenchao; Jefcoate, Colin R (2005) Steroidogenic factor-1 interacts with cAMP response element-binding protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer. Mol Pharmacol 67:499-512
Cho, Young C; Zheng, Wenchao; Yamamoto, Megumi et al. (2005) Differentiation of pluripotent C3H10T1/2 cells rapidly elevates CYP1B1 through a novel process that overcomes a loss of Ah Receptor. Arch Biochem Biophys 439:139-53
Cho, Young C; Zheng, Wenchao; Jefcoate, Colin R (2004) Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts. Toxicol Appl Pharmacol 199:220-38
Zheng, Wenchao; Brake, Paul B; Bhattacharyya, Kalyan K et al. (2003) Cell selective cAMP induction of rat CYP1B1 in adrenal and testis cells. Identification of a novel cAMP-responsive far upstream enhancer and a second Ah receptor-dependent mechanism. Arch Biochem Biophys 416:53-67
Zhang, Leying; Zheng, Wenchao; Jefcoate, Colin R (2003) Ah receptor regulation of mouse Cyp1B1 is additionally modulated by a second novel complex that forms at two AhR response elements. Toxicol Appl Pharmacol 192:174-90
Eltom, S E; Zhang, L; Jefcoate, C R (1999) Regulation of cytochrome P-450 (CYP) 1B1 in mouse Hepa-1 variant cell lines: A possible role for aryl hydrocarbon receptor nuclear translocator (ARNT) as a suppressor of CYP1B1 gene expression. Mol Pharmacol 55:594-604
Ikegwuonu, F I; Christou, M; Jefcoate, C R (1999) Regulation of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblast (C3H10T1/2) cells by protein kinase C (PKC). Biochem Pharmacol 57:619-30
Brake, P B; Arai, M; As-Sanie, S et al. (1999) Developmental expression and regulation of adrenocortical cytochrome P4501B1 in the rat. Endocrinology 140:1672-80
Alexander, D L; Zhang, L; Foroozesh, M et al. (1999) Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity. Toxicol Appl Pharmacol 161:123-39

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