Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA016502-22
Application #
2086493
Study Section
Experimental Virology Study Section (EVR)
Project Start
1983-02-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
22
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Boettiger, David (2007) Quantitative measurements of integrin-mediated adhesion to extracellular matrix. Methods Enzymol 426:1-25
Lee, Mark H; Ducheyne, Paul; Lynch, Laura et al. (2006) Effect of biomaterial surface properties on fibronectin-alpha5beta1 integrin interaction and cellular attachment. Biomaterials 27:1907-16
Lynch, Laura; Vodyanik, Pavel I; Boettiger, David et al. (2005) Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells. Mol Biol Cell 16:51-63
Lee, Fang-Hua; Haskell, Christopher; Charo, Isreal F et al. (2004) Receptor-ligand binding in the cell-substrate contact zone: a quantitative analysis using CX3CR1 and CXCR1 chemokine receptors. Biochemistry 43:7179-86
Guvakova, Marina A; Boettiger, David; Adams, Josephine C (2002) Induction of fascin spikes in breast cancer cells by activation of the insulin-like growth factor-I receptor. Int J Biochem Cell Biol 34:685-98
Datta, Anirban; Huber, Francois; Boettiger, David (2002) Phosphorylation of beta3 integrin controls ligand binding strength. J Biol Chem 277:3943-9
Garcia, Andres J; Schwarzbauer, Jean E; Boettiger, David (2002) Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin. Biochemistry 41:9063-9
Boettiger, D; Lynch, L; Blystone, S et al. (2001) Distinct ligand-binding modes for integrin alpha(v)beta(3)-mediated adhesion to fibronectin versus vitronectin. J Biol Chem 276:31684-90
Boettiger, D; Huber, F; Lynch, L et al. (2001) Activation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3. Mol Biol Cell 12:1227-37
Garcia, A J; Boettiger, D (1999) Integrin-fibronectin interactions at the cell-material interface: initial integrin binding and signaling. Biomaterials 20:2427-33

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