Abstract

This application proposes to clarify some of the confusing observations relative to the effects of dietary fat on the development of chemically-induced colon cancer in rats. We have analyzed literature reports in detail and concluded that variations in results may be affected by a number of factors including dietary levels and intake of calories and certain vitamins, strains of rat, route of carcinogen administration and duration of observation. These have been taken into account in the proposed experimental approach where nutritional control is assured.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA026917-05
Application #
3167505
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1980-01-01
Project End
1986-06-30
Budget Start
1985-01-01
Budget End
1986-06-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code

  Publications

Newberne, P M; Suphiphat, V; Locniskar, M et al. (1990) Inhibition of hepatocarcinogenesis in mice by dietary methyl donors methionine and choline. Nutr Cancer 14:175-81
Newberne, P M; Bueche, D; Suphiphat, V et al. (1990) The influence of pre- and postnatal caloric intake on colon carcinogenesis. Nutr Cancer 13:165-73
Newberne, P M; Bueche, D; Riengropitak, S et al. (1990) The influence of dietary levels of vitamin A and fat on colon cancer. Nutr Cancer 13:235-42
Nauss, K M; Jacobs, L R; Newberne, P M (1987) Dietary fat and fiber: relationship to caloric intake, body growth, and colon tumorigenesis. Am J Clin Nutr 45:243-51
Locniskar, M; Nauss, K M; Newberne, P M (1987) Natural killer cell activity and autologous mixed lymphocyte response of splenic, mesenteric lymph node, and colonic lymphocytes during DMH-induced colon carcinogenesis in the rat. Dig Dis Sci 32:747-52
Newberne, P M; Charnley, G; Adams, K et al. (1986) Gastric and oesophageal carcinogenesis: models for the identification of risk and protective factors. Food Chem Toxicol 24:1111-9
Locniskar, M; Nauss, K M; Newberne, P M (1986) Effect of colon tumor development and dietary fat on the immune system of rats treated with DMH. Nutr Cancer 8:73-84
Locniskar, M; Nauss, K M; Kauffman, P et al. (1985) Comparison of immune status and 1,2-dimethylhydrazine induced tumorigenesis in brown--Norway and Fischer rats. Emphasis on splenic and colonic lymphocyte function. Cancer Lett 25:311-23
Rogers, A E; Nauss, K M (1985) Rodent models for carcinoma of the colon. Dig Dis Sci 30:87S-102S