Abstract

The general objective of this research is to establish quantitative criteria for judging the potential for a therapeutic gain from alternative fractionation schemes in radiotherapy. More specifically, these studies aim at establishing estimates, for a given normal tissue, of (1) the smallest fractional dose at which a detectable increase in sparing occurs, and (2) the shortest interafraction interval for complete Elkind repair. Emphasis is placed on the application of applied mathematics to problems in experimental design and analysis, in which the objective is obtaining dose-response curves from in vivo assays of acute and late radiation injury. In particular, techniques are sought for obtaining quantitative, dose-response and repair kinetics parameters from qualitavie assays of early and late responses. These studies could ultimately provide guidelines for the use of hyperfractionated radiotherapy, through an understanding of the sites where it would be most beneficial and through and appreciation of the limits imposed on the number of daily treatments by the necessity for complete Elkind repair.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA029026-05
Application #
3168471
Study Section
Radiation Study Section (RAD)
Project Start
1980-12-01
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Thames, Howard D; Zhang, Ming; Tucker, Susan L et al. (2004) Cluster models of dose-volume effects. Int J Radiat Oncol Biol Phys 59:1491-504
Thames, Howard D; Petersen, Cordula; Petersen, Sven et al. (2002) Immunohistochemically detected p53 mutations in epithelial tumors and results of treatment with chemotherapy and radiotherapy. A treatment-specific overview of the clinical data. Strahlenther Onkol 178:411-21
Evans, S C; Mack, D C; Mason, K A et al. (2001) The proliferative response of mouse jejunal crypt cells to radiation-induced cell depletion is not mediated exclusively by transforming growth factor alpha. Radiat Res 155:866-9
Koscielny, S; Thames, H D (2001) Biased methods for estimating local and distant failure rates in breast carcinoma and a ""commonsense"" approach. Cancer 92:2220-7
Ruifrok, A C; Weil, M M; Thames, H D et al. (1998) Diurnal variations in the expression of radiation-induced apoptosis. Radiat Res 149:360-5
Powers, B E; Thames, H D; Gillette, S M et al. (1998) Volume effects in the irradiated canine spinal cord: do they exist when the probability of injury is low? Radiother Oncol 46:297-306
Ruifrok, A C; Weil, M M; Mason, K A et al. (1998) Induction of transforming growth factor alpha in irradiated mouse jejunum. Int J Radiat Oncol Biol Phys 42:1137-46
Thames, H D; Ang, K K (1998) Altered fractionation: radiobiological principles, clinical results, and potential for dose escalation. Cancer Treat Res 93:101-28
Ruifrok, A C; Mason, K A; Lozano, G et al. (1997) Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment. Radiat Res 147:1-12
Thames, H D; Ruifrok, A C; Mason, K A (1997) The effect of proliferative status and clonogen content on the response of mouse jejunal crypts to split-dose irradiation. Radiat Res 147:172-8

Showing the most recent 10 out of 61 publications