The application proposes a continuation of statistical research into problems arising in laboratory experiments designed to assess the potential hazards of food additives, drugs, cosmetics, and other chemicals. The long-term objectives are to develop methodologies for designing and interpreting these experiments. The specific problems to be addressed in the current proposal include: (1) Biases and efficiencies of existing methods for assessing carcinogenicity; (2) Theoretical and empirical studies of cause-of-death data; (3) Use of pathology information in analysis of tumor onset; (4) Adaptive sacrifice methods; and (5) Methods for rodent teratology experiments. Each of these topics will involve theoretical considerations, as well as extensive exploratory analyses of the ED01 experiment and other data sets.
| Lindsey, J C; Ryan, L M (1994) A comparison of continuous- and discrete- time three-state models for rodent tumorigenicity experiments. Environ Health Perspect 102 Suppl 1:9-17 |
| Herzberg, A M; Lagakos, S W (1992) Cage allocation designs for rodent carcinogenicity experiments. Environ Health Perspect 97:277-80 |
| Cheuvart, B; Ryan, L (1991) Adjusting for age-related competing mortality in long-term cancer clinical trials. Stat Med 10:65-77 |
| Amato, D A; Lagakos, S W (1988) Analysis of agreement among findings of pathologists in ED01 experiment. J Natl Cancer Inst 80:919-25 |
| Buyse, M; Ryan, L M (1987) Issues of efficiency in combining proportions of deaths from several clinical trials. Stat Med 6:565-76 |
| Ryan, L M (1985) Efficiency of age-adjusted tests in animal carcinogenicity experiments. Biometrics 41:525-31 |
| Lagakos, S W; Ryan, L M (1985) Statistical analysis of disease onset and lifetime data from tumorigenicity experiments. Environ Health Perspect 63:211-6 |
