Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA037799-12
Application #
2089432
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1984-08-01
Project End
2001-01-31
Budget Start
1996-03-09
Budget End
1997-01-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Bowlby, Deborah A; Brown, Theodore J; Hochberg, Richard B et al. (2016) In vitro Autoradiographic Analysis of Regional Changes in Estrogen Receptor Alpha in the Brains of Cycling Female Rats. Neuroendocrinology 103:538-51
Hanson, Robert N; Hua, Edward; Labaree, David et al. (2012) Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using ""click"" chemistry. Org Biomol Chem 10:8501-8
Hanson, Robert N; Hua, Edward; Hendricks, J Adam et al. (2012) Synthesis and evaluation of 11?-(4-substituted phenyl) estradiol analogs: transition from estrogen receptor agonists to antagonists. Bioorg Med Chem 20:3768-80
Hanson, Robert N; McCaskill, Emmett; Tongcharoensirikul, Pakamas et al. (2012) Synthesis and evaluation of 17?-(dimethylphenyl)vinyl estradiols as probes of the estrogen receptor-? ligand binding domain. Steroids 77:471-6
Olmsted, Sandra L; Tongcharoensirikul, Pakamas; McCaskill, Emmett et al. (2012) Synthesis and evaluation of 17?-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17?-diols [17?-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-? ligand binding domain (ER?-LBD). Bioorg Med Chem Lett 22:977-9
Haddad, Terra; Gershman, Rachel; Dilis, Robert et al. (2012) Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor. Bioorg Med Chem Lett 22:5999-6003
Hanson, Robert N; Kirss, Rein; McCaskill, Emmett et al. (2012) Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol. Bioorg Med Chem Lett 22:1670-3
Nettles, Kendall W; Bruning, John B; Gil, German et al. (2008) NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. Nat Chem Biol 4:241-7
McCarthy, Thomas L; Hochberg, Richard B; Labaree, David C et al. (2007) 3-ketosteroid reductase activity and expression by fetal rat osteoblasts. J Biol Chem 282:34003-12
Kahn, Michael G C; Konde, Emmanuel; Dossou, Francis et al. (2006) Microwave-enhanced nucleophilic fluorination in the synthesis of fluoropyridyl derivatives of [3,2-c]pyrazolo-corticosteroids, potential glucocorticoid receptor-mediated imaging agents. Bioorg Med Chem Lett 16:3454-8

Showing the most recent 10 out of 53 publications