Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037831-11
Application #
2089442
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1984-08-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Other Basic Sciences
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Liu, Chunhua; Kim, Eunsuk; Demple, Bruce et al. (2012) A DNA-based nanomechanical device used to characterize the distortion of DNA by Apo-SoxR protein. Biochemistry 51:937-43
Lee, Paul E; Demple, Bruce; Barton, Jacqueline K (2009) DNA-mediated redox signaling for transcriptional activation of SoxR. Proc Natl Acad Sci U S A 106:13164-8
Lee, Yunho; Pena-Llopis, Samuel; Kang, Yoon-Suk et al. (2006) Expression analysis of the fpr (ferredoxin-NADP+ reductase) gene in Pseudomonas putida KT2440. Biochem Biophys Res Commun 339:1246-54
Park, Woojun; Pena-Llopis, Samuel; Lee, Yunho et al. (2006) Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coli. Biochem Biophys Res Commun 341:51-6
Koutsolioutsou, Anastasia; Pena-Llopis, Samuel; Demple, Bruce (2005) Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates. Antimicrob Agents Chemother 49:2746-52
Chander, Monica; Demple, Bruce (2004) Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression. J Biol Chem 279:41603-10
Pomposiello, Pablo J; Koutsolioutsou, Anastasia; Carrasco, Daniel et al. (2003) SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli. J Bacteriol 185:6624-32
Chander, Monica; Raducha-Grace, Laura; Demple, Bruce (2003) Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization. J Bacteriol 185:2441-50
Koutsolioutsou, A; Martins, E A; White, D G et al. (2001) A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium). Antimicrob Agents Chemother 45:38-43
Pomposiello, P J; Bennik, M H; Demple, B (2001) Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate. J Bacteriol 183:3890-902

Showing the most recent 10 out of 61 publications