Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039504-11
Application #
2089852
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1986-03-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Penning, Trevor M (2015) The aldo-keto reductases (AKRs): Overview. Chem Biol Interact 234:236-46
Penning, Trevor M (2014) Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons. Chem Res Toxicol 27:1901-17
Zhang, Li; Huang, Meng; Blair, Ian A et al. (2013) Interception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cells. Chem Res Toxicol 26:1570-8
Huang, Meng; Blair, Ian A; Penning, Trevor M (2013) Identification of stable benzo[a]pyrene-7,8-dione-DNA adducts in human lung cells. Chem Res Toxicol 26:685-92
Zhang, Li; Jin, Yi; Huang, Meng et al. (2012) The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones. Front Pharmacol 3:193
Huang, Meng; Liu, Xiaojing; Basu, Sankha S et al. (2012) Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct. Chem Res Toxicol 25:993-1003
Zhang, Li; Huang, Meng; Blair, Ian A et al. (2012) Detoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTs) in human lung cells. J Biol Chem 287:29909-20
Zhang, Li; Jin, Yi; Chen, Mo et al. (2011) Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols. J Biol Chem 286:25644-54
Shultz, Carol A; Quinn, Amy M; Park, Jong-Heum et al. (2011) Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone. Chem Res Toxicol 24:2153-66
Wu, Anhui; Duan, Yazhen; Xu, Daiwang et al. (2010) Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents. Tetrahedron 66:2111-2118

Showing the most recent 10 out of 72 publications