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Wolfe, Alan R; Smith, Timothy J; Meehan, Thomas (2004) Benzo[a]pyrene diol epoxide forms covalent adducts with deoxycytidylic acid by alkylation at both exocyclic amino N(4) and ring imino N-3 positions. Chem Res Toxicol 17:476-91
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Vock, E H; Wolfe, A R; Meehan, T (2001) Trans- and cis-DNA adduct concentration in epidermis from mouse and rat skin treated ex vivo with benzo[a]pyrene diol epoxide and its corresponding chlorohydrin. Mutat Res 478:199-206
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Song, Q; Negrete, G R; Wolfe, A R et al. (1998) Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol 11:1057-66
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Meehan, T; Wolfe, A R; Negrete, G R et al. (1997) Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate. Proc Natl Acad Sci U S A 94:1749-54
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Wolfe, A R; Meehan, T (1994) The effect of sodium ion concentration on intrastrand base-pairing in single-stranded DNA. Nucleic Acids Res 22:3147-50
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Wolfe, A R; Yamamoto, J; Meehan, T (1994) Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids. Proc Natl Acad Sci U S A 91:1371-5
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Wolfe, A R; Meehan, T (1992) Use of binding site neighbor-effect parameters to evaluate the interactions between adjacent ligands on a linear lattice. Effects on ligand-lattice association. J Mol Biol 223:1063-87
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Yamamoto, J; Subramaniam, R; Wolfe, A R et al. (1990) The formation of covalent adducts between benzo[a]pyrenediol epoxide and RNA: structural analysis by mass spectrometry. Biochemistry 29:3966-72
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Shimer Jr, G H; Wolfe, A R; Meehan, T (1988) Equilibrium binding of benzo[a]pyrene tetrol to synthetic polynucleotides: sequence selectivity, thermodynamic properties, and ionic strength dependence. Biochemistry 27:7960-6
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Wolfe, A; Shimer Jr, G H; Meehan, T (1987) Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA. Biochemistry 26:6392-6
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