Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA042533-05S1
Application #
3183984
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-04-01
Project End
1994-03-31
Budget Start
1990-04-25
Budget End
1991-03-31
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Biggs, Joseph R; Peterson, Luke F; Zhang, Youhong et al. (2006) AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol Cell Biol 26:7420-9
Biggs, Joseph R; Zhang, Youhong; Peterson, Luke F et al. (2005) Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association. Mol Cancer Res 3:391-401
Zhang, Youhong; Biggs, Joseph R; Kraft, Andrew S (2004) Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation. J Biol Chem 279:53116-25
Biggs, J R; Yang, J; Gullberg, U et al. (2001) The human brm protein is cleaved during apoptosis: the role of cathepsin G. Proc Natl Acad Sci U S A 98:3814-9
Matsuguchi, T; Musikacharoen, T; Johnson, T R et al. (2001) A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines. Mol Cell Biol 21:6999-7009
Johnson, T R; Biggs, J R; Winbourn, S E et al. (2000) Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain. J Biol Chem 275:31755-62
Biggs, J R; Kraft, A S (1999) The role of the Smad3 protein in phorbol ester-induced promoter expression. J Biol Chem 274:36987-94
Burgess, G S; Williamson, E A; Cripe, L D et al. (1998) Regulation of the c-jun gene in p210 BCR-ABL transformed cells corresponds with activity of JNK, the c-jun N-terminal kinase. Blood 92:2450-60
Franklin, C C; Srikanth, S; Kraft, A S (1998) Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Proc Natl Acad Sci U S A 95:3014-9
Biggs, J R; Ahn, N G; Kraft, A S (1998) Activation of the mitogen-activated protein kinase pathway in U937 leukemic cells induces phosphorylation of the amino terminus of the TATA-binding protein. Cell Growth Differ 9:667-76

Showing the most recent 10 out of 46 publications