The overall goal of the proposed research is the development of novel polymerized and unpolymerized vesicle systems for targeted drug delivery in cancer treatment. These systems will be based on cleavable surfactants. A surfactant is cleavable if it contains a linkage separating its hydrophilic and lipophilic portions that is stable under some conditions but labile under others. Cleavage at the linkage converts the surfactant into non-surfactant compounds, and it would therefore result in rupture of a cleavable surfactantbased vesicle with concomitant release of an entrapped compound. Both pH and UVsensitive linkages will be employed. The former will allow targeting to tumors, which can have lower pH's than normal tissue. The exact nature of the linkage and the polymerized/unpolymerized character will be varied to give a series of targeted vesicles with a wide spectrum of release kinetics that would otherwise be difficult if not impossible to obtain. Detailed goals are as follows: (1) the preparation of doublechain, cleavable surfactants and polymerized analogues; (2) the characterization of polymerized and unpolymerized vesicles formulated from them; (3) the demonstration that such vesicles have potential for drug delivery in cancer treatment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA045769-03
Application #
3189041
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1987-09-01
Project End
1991-08-31
Budget Start
1990-03-01
Budget End
1991-08-31
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Wyoming
Department
Type
Schools of Arts and Sciences
DUNS #
069690956
City
Laramie
State
WY
Country
United States
Zip Code
82071