Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA046595-02
Application #
3189918
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-02-08
Project End
1989-08-31
Budget Start
1989-02-01
Budget End
1989-08-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
School of Medicine & Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Schild, Tanya; Low, Vivien; Blenis, John et al. (2018) Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization. Cancer Cell 33:347-354
Gomes, Ana P; Schild, Tanya; Blenis, John (2017) Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer. Dev Cell 42:112-114
Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A et al. (2017) Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Mol Cell 67:512-527.e4
Lee, Gina; Zheng, Yuxiang; Cho, Sungyun et al. (2017) Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell 171:1545-1558.e18
Mendoza, Michelle C; Vilela, Marco; Juarez, Jesus E et al. (2015) ERK reinforces actin polymerization to power persistent edge protrusion during motility. Sci Signal 8:ra47
Gomes, Ana P; Blenis, John (2015) A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. Curr Opin Biotechnol 34:110-7
Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura et al. (2015) ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Mol Cell 59:382-98
Galan, Jacob A; Geraghty, Kathryn M; Lavoie, Geneviève et al. (2014) Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proc Natl Acad Sci U S A 111:E2918-27
Csibi, Alfredo; Lee, Gina; Yoon, Sang-Oh et al. (2014) The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Curr Biol 24:2274-80
Li, Jing; Kim, Sang Gyun; Blenis, John (2014) Rapamycin: one drug, many effects. Cell Metab 19:373-9

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