Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA051162-02
Application #
3195879
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-04-01
Project End
1993-06-30
Budget Start
1993-04-01
Budget End
1993-06-30
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Krishnaraju, K; Hoffman, B; Liebermann, D A (2001) Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages. Blood 97:1298-305
Amanullah, A; Hoffman, B; Liebermann, D A (2000) Deregulated E2F-1 blocks terminal differentiation and loss of leukemogenicity of M1 myeloblastic leukemia cells without abrogating induction of p15(INK4B) and p16(INK4A). Blood 96:475-82
Zhang, W; Bae, I; Krishnaraju, K et al. (1999) CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene 18:4899-907
Liebermann, D A; Gregory, B; Hoffman, B (1998) AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol 12:685-700
Guillouf, C; Rosselli, F; Sjin, R T et al. (1998) Role of a mutant p53 protein in apoptosis: characterization of a function independent of transcriptional trans-activation. Int J Oncol 13:107-14
Krishnaraju, K; Hoffman, B; Liebermann, D A (1998) The zinc finger transcription factor Egr-1 activates macrophage differentiation in M1 myeloblastic leukemia cells. Blood 92:1957-66
Selvakumaran, M; Liebermann, D; Hoffman, B (1996) The proto-oncogene c-myc blocks myeloid differentiation independently of its target gene ornithine decarboxylase. Blood 88:1248-55
Bies, J; Hoffman, B; Amanullah, A et al. (1996) B-Myb prevents growth arrest associated with terminal differentiation of monocytic cells. Oncogene 12:355-63
Hoffman, B; Liebermann, D A; Selvakumaran, M et al. (1996) Role of c-myc in myeloid differentiation, growth arrest and apoptosis. Curr Top Microbiol Immunol 211:17-27
Wen, S C; Ku, D H; De Luca, A et al. (1995) ets-2 regulates cdc2 kinase activity in mammalian cells: coordinated expression of cdc2 and cyclin A. Exp Cell Res 217:8-14

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