Abstract

We propose to conduct a sigmoidoscopy-based case-control study of nutritional factors in the etiology of adenomatous polyps of the large bowel. There will be 530 cases identified from sigmoidoscopy as having a first time diagnosis of at least one adenomatous polyp. Five hundred and thirty controls, matched by age, gender, and calendar date of exam, will be selected from subjects who were found to be free of polyps at the sigmoidoscopy. The study will be restricted to asymptomatic subjects with no history of polyps. Data will be obtained from a self-administered dietary questionnaire (Walter Willetts'), nondietary risk factor questionnaire (in-person interview), blood sample, and, from cases only, pathology specimens. Dietary factors of particular interest include fat (various types and sources), fiber (various types), calories, cholesterol (including HDL/LDL fractions), calcium, alcohol, beta-carotene, and vitamins C and E. Blood samples will be analyzed for beta-carotene and vitamins C and E. Nondietary risk factors of interest include physical activity, hormones, and smoking. Main effects and interactions will be estimated with prevalence odds ratios, using stratified analysis and unconditional logistic regression.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA051923-04
Application #
2094452
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1991-02-01
Project End
1995-01-31
Budget Start
1994-03-01
Budget End
1995-01-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Tippin, Brigette L; Levine, A Joan; Materi, Alicia M et al. (2012) Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer. Prostaglandins Other Lipid Mediat 97:22-8
Levine, A Joan; Win, Aung Ko; Buchanan, Daniel D et al. (2012) Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry. Cancer Prev Res (Phila) 5:328-35
Lin, Henry J; Zhou, Haiyan; Dai, Aihua et al. (2002) Glutathione transferase GSTT1, broccoli, and prevalence of colorectal adenomas. Pharmacogenetics 12:175-9
Lin, Henry J; Lakkides, Karen M; Keku, Temitope O et al. (2002) Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. Cancer Epidemiol Biomarkers Prev 11:1305-15
Cortessis, V; Siegmund, K; Chen, Q et al. (2001) A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas. Cancer Res 61:2381-5
Wang, W; Xue, S; Ingles, S A et al. (2001) An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 10:931-6
Levine, A J; Siegmund, K D; Ervin, C M et al. (2000) The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 9:657-63
McKelvey, W; Greenland, S; Chen, M J et al. (1999) A case-control study of colorectal adenomatous polyps and consumption of foods containing partially hydrogenated oils. Cancer Epidemiol Biomarkers Prev 8:519-24
Bird, C L; Frankl, H D; Lee, E R et al. (1998) Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum. Am J Epidemiol 147:670-80
Ingles, S A; Bird, C L; Shikany, J M et al. (1998) Plasma tocopherol and prevalence of colorectal adenomas in a multiethnic population. Cancer Res 58:661-6

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