The investigator proposes to extend group sequential methods for early stopping of clinical trials and epidemiologic studies.
The specific aims of the proposal are: 1) to develop group-sequential methods for clinical trials in which some portion of the patients are considered cured of the disease, 2) to develop group-sequential methods for clinical trials with repeated measures, e.g., longitudinal studies, potentially with missing data, 3) to develop group-sequential methods for epidemiologic studies such as retrospective case-control studies and prospective cohort studies, and 4) to develop """"""""work-arounds"""""""" to the problem of 'overrunning' and 'underrunning' the maximum information in long-term clinical trials. Development of practical guidelines for implementation of the proposed methods will be emphasized, and data from clinical trials will be utilized in investigating the practical aspects of the proposed methods. The group sequential methods rely primarily on a design paradigm using the Lan-DeMets (1983) type I error spending function approach, which can be implemented in a standard way when an 'independent increments' structure of sequentially computed test statistics is established.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA052733-08
Application #
2894846
Study Section
Special Emphasis Panel (ZRG7-STA (01))
Program Officer
Erickson, Burdette (BUD) W
Project Start
1990-07-05
Project End
2002-08-31
Budget Start
1999-09-01
Budget End
2002-08-31
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Jung, S H; Carey, M; Kim, K M (2001) Graphical search for two-stage designs for phase II clinical trials. Control Clin Trials 22:367-72