Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055042-06
Application #
2096281
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1991-07-02
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Other Basic Sciences
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Jordan, Jennifer J; Chhim, Sophea; Margulies, Carrie M et al. (2017) ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death Dis 8:e2947
Chaim, Isaac A; Nagel, Zachary D; Jordan, Jennifer J et al. (2017) In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities. Proc Natl Acad Sci U S A 114:E10379-E10388
Calvo, Jennifer A; Allocca, Mariacarmela; Fake, Kimberly R et al. (2016) Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner. Oncotarget 7:44950-44965
Fu, Dragony; Samson, Leona D; Hübscher, Ullrich et al. (2015) The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants. DNA Repair (Amst) 35:13-8
Meira, Lisiane B; Calvo, Jennifer A; Shah, Dharini et al. (2014) Repair of endogenous DNA base lesions modulate lifespan in mice. DNA Repair (Amst) 21:78-86
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Calvo, Jennifer A; Moroski-Erkul, Catherine A; Lake, Annabelle et al. (2013) Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. PLoS Genet 9:e1003413
Mazumder, Aprotim; Pesudo, Laia Quiros; McRee, Siobhan et al. (2013) Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae. Nucleic Acids Res 41:9310-24
Mazumder, Aprotim; Tummler, Katja; Bathe, Mark et al. (2013) Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage. Mol Cell Biol 33:635-42
Svensson, J Peter; Quirós Pesudo, Laia; McRee, Siobhan K et al. (2013) Genomic phenotyping by barcode sequencing broadly distinguishes between alkylating agents, oxidizing agents, and non-genotoxic agents, and reveals a role for aromatic amino acids in cellular recovery after quinone exposure. PLoS One 8:e73736

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